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Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
To examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785733/ https://www.ncbi.nlm.nih.gov/pubmed/33402695 http://dx.doi.org/10.1038/s41531-020-00145-8 |
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author | Liu, Bojing Sjölander, Arvid Pedersen, Nancy L. Ludvigsson, Jonas F. Chen, Honglei Fang, Fang Wirdefeldt, Karin |
author_facet | Liu, Bojing Sjölander, Arvid Pedersen, Nancy L. Ludvigsson, Jonas F. Chen, Honglei Fang, Fang Wirdefeldt, Karin |
author_sort | Liu, Bojing |
collection | PubMed |
description | To examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD. |
format | Online Article Text |
id | pubmed-7785733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77857332021-01-14 Irritable bowel syndrome and Parkinson’s disease risk: register-based studies Liu, Bojing Sjölander, Arvid Pedersen, Nancy L. Ludvigsson, Jonas F. Chen, Honglei Fang, Fang Wirdefeldt, Karin NPJ Parkinsons Dis Article To examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD. Nature Publishing Group UK 2021-01-05 /pmc/articles/PMC7785733/ /pubmed/33402695 http://dx.doi.org/10.1038/s41531-020-00145-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Liu, Bojing Sjölander, Arvid Pedersen, Nancy L. Ludvigsson, Jonas F. Chen, Honglei Fang, Fang Wirdefeldt, Karin Irritable bowel syndrome and Parkinson’s disease risk: register-based studies |
title | Irritable bowel syndrome and Parkinson’s disease risk: register-based studies |
title_full | Irritable bowel syndrome and Parkinson’s disease risk: register-based studies |
title_fullStr | Irritable bowel syndrome and Parkinson’s disease risk: register-based studies |
title_full_unstemmed | Irritable bowel syndrome and Parkinson’s disease risk: register-based studies |
title_short | Irritable bowel syndrome and Parkinson’s disease risk: register-based studies |
title_sort | irritable bowel syndrome and parkinson’s disease risk: register-based studies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785733/ https://www.ncbi.nlm.nih.gov/pubmed/33402695 http://dx.doi.org/10.1038/s41531-020-00145-8 |
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