Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative

p97, also known as valosin-containing protein (VCP) or Cdc48, plays a central role in cellular protein homeostasis. Human p97 mutations are associated with several neurodegenerative diseases. Targeting p97 and its cofactors is a strategy for cancer drug development. Despite significant structural in...

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Detalles Bibliográficos
Autores principales: Pan, Man, Zheng, Qingyun, Yu, Yuanyuan, Ai, Huasong, Xie, Yuan, Zeng, Xin, Wang, Chu, Liu, Lei, Zhao, Minglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785736/
https://www.ncbi.nlm.nih.gov/pubmed/33402676
http://dx.doi.org/10.1038/s41467-020-20359-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785736/
https://www.ncbi.nlm.nih.gov/pubmed/33402676
http://dx.doi.org/10.1038/s41467-020-20359-x

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