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Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative
p97, also known as valosin-containing protein (VCP) or Cdc48, plays a central role in cellular protein homeostasis. Human p97 mutations are associated with several neurodegenerative diseases. Targeting p97 and its cofactors is a strategy for cancer drug development. Despite significant structural in...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785736/ https://www.ncbi.nlm.nih.gov/pubmed/33402676 http://dx.doi.org/10.1038/s41467-020-20359-x |