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Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report

BACKGROUND: Erythropoietic protoporphyria (EPP) is a rare disorder of heme synthesis. Patients with EPP mainly show symptoms of photosensitivity, but approximately 20% of EPPs are associated with the liver-related complications. We report a case of breast cancer in a 48-year-old female patient with...

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Autores principales: Shimazaki, Akiko, Hashimoto, Takuma, Kai, Masaya, Nakayama, Tetsuzo, Yamada, Mai, Zaguirre, Karen, Tokuda, Kentaro, Kubo, Makoto, Yamaura, Ken, Nakamura, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785757/
https://www.ncbi.nlm.nih.gov/pubmed/33400006
http://dx.doi.org/10.1186/s40792-020-01068-5
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author Shimazaki, Akiko
Hashimoto, Takuma
Kai, Masaya
Nakayama, Tetsuzo
Yamada, Mai
Zaguirre, Karen
Tokuda, Kentaro
Kubo, Makoto
Yamaura, Ken
Nakamura, Masafumi
author_facet Shimazaki, Akiko
Hashimoto, Takuma
Kai, Masaya
Nakayama, Tetsuzo
Yamada, Mai
Zaguirre, Karen
Tokuda, Kentaro
Kubo, Makoto
Yamaura, Ken
Nakamura, Masafumi
author_sort Shimazaki, Akiko
collection PubMed
description BACKGROUND: Erythropoietic protoporphyria (EPP) is a rare disorder of heme synthesis. Patients with EPP mainly show symptoms of photosensitivity, but approximately 20% of EPPs are associated with the liver-related complications. We report a case of breast cancer in a 48-year-old female patient with EPP in whom meticulous perioperative management was required in order to avoid complications resulting from this disease. CASE PRESENTATION: The patient was diagnosed with EPP at the age of 33 and had a rich family history of the disease. For right breast cancer initially considered as TisN0M0 (Stage 0), the right mastectomy and sentinel lymph node biopsy were performed, while the final stage was pT1bN0M0, pStage I. In the perioperative period, we limited the drug use and monitored light wavelength measurements. Besides, we covered surgical lights, headlights, and laryngoscope’s light with a special polyimide film that filtered the wavelength of light causing dermal photosensitivity. After the surgery, any emerging complications were closely monitored. CONCLUSIONS: The surgery, internal medicine, anesthesiology, and operation departments undertook all possible measures through close cooperation to ensure a safe surgery for the patient with a rare condition.
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spelling pubmed-77857572021-01-14 Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report Shimazaki, Akiko Hashimoto, Takuma Kai, Masaya Nakayama, Tetsuzo Yamada, Mai Zaguirre, Karen Tokuda, Kentaro Kubo, Makoto Yamaura, Ken Nakamura, Masafumi Surg Case Rep Case Report BACKGROUND: Erythropoietic protoporphyria (EPP) is a rare disorder of heme synthesis. Patients with EPP mainly show symptoms of photosensitivity, but approximately 20% of EPPs are associated with the liver-related complications. We report a case of breast cancer in a 48-year-old female patient with EPP in whom meticulous perioperative management was required in order to avoid complications resulting from this disease. CASE PRESENTATION: The patient was diagnosed with EPP at the age of 33 and had a rich family history of the disease. For right breast cancer initially considered as TisN0M0 (Stage 0), the right mastectomy and sentinel lymph node biopsy were performed, while the final stage was pT1bN0M0, pStage I. In the perioperative period, we limited the drug use and monitored light wavelength measurements. Besides, we covered surgical lights, headlights, and laryngoscope’s light with a special polyimide film that filtered the wavelength of light causing dermal photosensitivity. After the surgery, any emerging complications were closely monitored. CONCLUSIONS: The surgery, internal medicine, anesthesiology, and operation departments undertook all possible measures through close cooperation to ensure a safe surgery for the patient with a rare condition. Springer Berlin Heidelberg 2021-01-05 /pmc/articles/PMC7785757/ /pubmed/33400006 http://dx.doi.org/10.1186/s40792-020-01068-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Shimazaki, Akiko
Hashimoto, Takuma
Kai, Masaya
Nakayama, Tetsuzo
Yamada, Mai
Zaguirre, Karen
Tokuda, Kentaro
Kubo, Makoto
Yamaura, Ken
Nakamura, Masafumi
Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
title Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
title_full Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
title_fullStr Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
title_full_unstemmed Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
title_short Surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
title_sort surgical treatment for breast cancer in a patient with erythropoietic protoporphyria and photosensitivity: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785757/
https://www.ncbi.nlm.nih.gov/pubmed/33400006
http://dx.doi.org/10.1186/s40792-020-01068-5
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