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Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression

Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into th...

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Autores principales: Qi, Bill, MacDonald, Kellie, Berlim, Marcelo T., Fielding, Allan, Lis, Eric, Low, Nancy, Richard-Devantoy, Stéphane, Tourjman, Valerie, Turecki, Gustavo, Trakadis, Yannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785784/
https://www.ncbi.nlm.nih.gov/pubmed/33424654
http://dx.doi.org/10.3389/fpsyt.2020.567394
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author Qi, Bill
MacDonald, Kellie
Berlim, Marcelo T.
Fielding, Allan
Lis, Eric
Low, Nancy
Richard-Devantoy, Stéphane
Tourjman, Valerie
Turecki, Gustavo
Trakadis, Yannis
author_facet Qi, Bill
MacDonald, Kellie
Berlim, Marcelo T.
Fielding, Allan
Lis, Eric
Low, Nancy
Richard-Devantoy, Stéphane
Tourjman, Valerie
Turecki, Gustavo
Trakadis, Yannis
author_sort Qi, Bill
collection PubMed
description Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into three roughly equal depression severity levels based on scores from the APA Severity Measure for Depression—Adult (n = 66, 58, 60, for low, medium, high severity, respectively). We saw a significant and gradual increase in the frequency of “muscular paralysis” (1.5–5.2–16.7%) and “balance problems” (21.2–36.2–46.6%) from low to medium to high severity groups. We repeated the analysis using only the two most extreme severity categories: low severity (66 samples) vs. high severity (60 samples). High severity patients were also found to experience more “angina” symptoms than low severity patients (27.3 vs. 50%). The three significant clinical variables identified were introduced into a binary logistic regression model as the independent variables with high or low severity as the dependent variable. Both “muscular paralysis” and “balance problems” were significantly associated with increased severity of depression (odds ratio of 13.5 and 2.9, respectively), while “angina” was associated with an increase in severity with an odds ratio of 2.0, albeit not significantly. We show that neurological exam or clinical history could be useful biomarkers for depression severity. Our findings, if replicated, could lead to a simple clinical scale administered regularly for monitoring patients with MDD.
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spelling pubmed-77857842021-01-07 Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression Qi, Bill MacDonald, Kellie Berlim, Marcelo T. Fielding, Allan Lis, Eric Low, Nancy Richard-Devantoy, Stéphane Tourjman, Valerie Turecki, Gustavo Trakadis, Yannis Front Psychiatry Psychiatry Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into three roughly equal depression severity levels based on scores from the APA Severity Measure for Depression—Adult (n = 66, 58, 60, for low, medium, high severity, respectively). We saw a significant and gradual increase in the frequency of “muscular paralysis” (1.5–5.2–16.7%) and “balance problems” (21.2–36.2–46.6%) from low to medium to high severity groups. We repeated the analysis using only the two most extreme severity categories: low severity (66 samples) vs. high severity (60 samples). High severity patients were also found to experience more “angina” symptoms than low severity patients (27.3 vs. 50%). The three significant clinical variables identified were introduced into a binary logistic regression model as the independent variables with high or low severity as the dependent variable. Both “muscular paralysis” and “balance problems” were significantly associated with increased severity of depression (odds ratio of 13.5 and 2.9, respectively), while “angina” was associated with an increase in severity with an odds ratio of 2.0, albeit not significantly. We show that neurological exam or clinical history could be useful biomarkers for depression severity. Our findings, if replicated, could lead to a simple clinical scale administered regularly for monitoring patients with MDD. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7785784/ /pubmed/33424654 http://dx.doi.org/10.3389/fpsyt.2020.567394 Text en Copyright © 2020 Qi, MacDonald, Berlim, Fielding, Lis, Low, Richard-Devantoy, Tourjman, Turecki and Trakadis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Qi, Bill
MacDonald, Kellie
Berlim, Marcelo T.
Fielding, Allan
Lis, Eric
Low, Nancy
Richard-Devantoy, Stéphane
Tourjman, Valerie
Turecki, Gustavo
Trakadis, Yannis
Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
title Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
title_full Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
title_fullStr Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
title_full_unstemmed Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
title_short Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
title_sort balance problems, paralysis, and angina as clinical markers for severity in major depression
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785784/
https://www.ncbi.nlm.nih.gov/pubmed/33424654
http://dx.doi.org/10.3389/fpsyt.2020.567394
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