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The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment
The female reproductive tract microenvironment includes microorganisms, metabolites, and immune components, and the balance of the interactions among them plays an important role in maintaining female reproductive tract homeostasis and health. When any one of the reproductive tract microorganisms, m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785791/ https://www.ncbi.nlm.nih.gov/pubmed/33425785 http://dx.doi.org/10.3389/fcimb.2020.609488 |
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author | Li, Huanrong Zang, Yuqin Wang, Chen Li, Huiyang Fan, Aiping Han, Cha Xue, Fengxia |
author_facet | Li, Huanrong Zang, Yuqin Wang, Chen Li, Huiyang Fan, Aiping Han, Cha Xue, Fengxia |
author_sort | Li, Huanrong |
collection | PubMed |
description | The female reproductive tract microenvironment includes microorganisms, metabolites, and immune components, and the balance of the interactions among them plays an important role in maintaining female reproductive tract homeostasis and health. When any one of the reproductive tract microorganisms, metabolites, or immunity is out of balance, it will affect the other two, leading to the occurrence and development of diseases and the appearance of corresponding symptoms and signs, such as infertility, miscarriage, premature delivery, and gynecological tumors caused by infectious diseases of the reproductive tract. Nutrients in the female reproductive tract provide symbiotic and pathogenic microorganisms with a source of nutrients for their own reproduction and utilization. At the same time, this interaction with the host forms a variety of metabolites. Changes in metabolites in the host reproductive tract are related not only to the interaction between the host and microbiota under dysbiosis but also to changes in host immunity or the environment, all of which will participate in the pathogenesis of diseases and lead to disease-related phenotypes. Microorganisms and their metabolites can also interact with host immunity, activate host immunity, and change the host immune status and are closely related to persistent genital pathogen infections, aggravation of infectious diseases, severe pregnancy outcomes, and even gynecological cancers. Therefore, studying the interaction between microorganisms, metabolites, and immunity in the reproductive tract cannot only reveal the pathogenic mechanisms that lead to inflammation of the reproductive tract, adverse pregnancy outcomes and tumorigenesis but also provide a basis for further research on the diagnosis and treatment of targets. |
format | Online Article Text |
id | pubmed-7785791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77857912021-01-07 The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment Li, Huanrong Zang, Yuqin Wang, Chen Li, Huiyang Fan, Aiping Han, Cha Xue, Fengxia Front Cell Infect Microbiol Cellular and Infection Microbiology The female reproductive tract microenvironment includes microorganisms, metabolites, and immune components, and the balance of the interactions among them plays an important role in maintaining female reproductive tract homeostasis and health. When any one of the reproductive tract microorganisms, metabolites, or immunity is out of balance, it will affect the other two, leading to the occurrence and development of diseases and the appearance of corresponding symptoms and signs, such as infertility, miscarriage, premature delivery, and gynecological tumors caused by infectious diseases of the reproductive tract. Nutrients in the female reproductive tract provide symbiotic and pathogenic microorganisms with a source of nutrients for their own reproduction and utilization. At the same time, this interaction with the host forms a variety of metabolites. Changes in metabolites in the host reproductive tract are related not only to the interaction between the host and microbiota under dysbiosis but also to changes in host immunity or the environment, all of which will participate in the pathogenesis of diseases and lead to disease-related phenotypes. Microorganisms and their metabolites can also interact with host immunity, activate host immunity, and change the host immune status and are closely related to persistent genital pathogen infections, aggravation of infectious diseases, severe pregnancy outcomes, and even gynecological cancers. Therefore, studying the interaction between microorganisms, metabolites, and immunity in the reproductive tract cannot only reveal the pathogenic mechanisms that lead to inflammation of the reproductive tract, adverse pregnancy outcomes and tumorigenesis but also provide a basis for further research on the diagnosis and treatment of targets. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7785791/ /pubmed/33425785 http://dx.doi.org/10.3389/fcimb.2020.609488 Text en Copyright © 2020 Li, Zang, Wang, Li, Fan, Han and Xue http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Li, Huanrong Zang, Yuqin Wang, Chen Li, Huiyang Fan, Aiping Han, Cha Xue, Fengxia The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment |
title | The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment |
title_full | The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment |
title_fullStr | The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment |
title_full_unstemmed | The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment |
title_short | The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment |
title_sort | interaction between microorganisms, metabolites, and immune system in the female genital tract microenvironment |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785791/ https://www.ncbi.nlm.nih.gov/pubmed/33425785 http://dx.doi.org/10.3389/fcimb.2020.609488 |
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