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BCGitis as the primary manifestation of chronic granulomatous disease

Patients with primary immunodeficiency disease (PID) are not only vulnerable to mycobacterial disease, but are also more likely to develop adverse events following BCG vaccination. These events can range from regional disease (BCGitis) to disseminated disease (BCGosis). Chronic granulomatous disease...

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Autores principales: Khalili, Nastaran, Mohammadzadeh, Iraj, Khalili, Neda, Heredia, Raúl Jimenez, Zoghi, Samaneh, Boztug, Kaan, Rezaei, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785948/
https://www.ncbi.nlm.nih.gov/pubmed/33425681
http://dx.doi.org/10.1016/j.idcr.2020.e01038
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author Khalili, Nastaran
Mohammadzadeh, Iraj
Khalili, Neda
Heredia, Raúl Jimenez
Zoghi, Samaneh
Boztug, Kaan
Rezaei, Nima
author_facet Khalili, Nastaran
Mohammadzadeh, Iraj
Khalili, Neda
Heredia, Raúl Jimenez
Zoghi, Samaneh
Boztug, Kaan
Rezaei, Nima
author_sort Khalili, Nastaran
collection PubMed
description Patients with primary immunodeficiency disease (PID) are not only vulnerable to mycobacterial disease, but are also more likely to develop adverse events following BCG vaccination. These events can range from regional disease (BCGitis) to disseminated disease (BCGosis). Chronic granulomatous disease (CGD), which is characterized by impaired leukocyte phagocytic function, is one of the many inherited PIDs that increase the body’s susceptibility to recurrent bacterial and fungal infections. Here, we report a 6-year-old boy with no significant past medical history who presented with progressive lymphadenopathy six years after BCG vaccination. He was later diagnosed with CGD on further evaluation.
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spelling pubmed-77859482021-01-08 BCGitis as the primary manifestation of chronic granulomatous disease Khalili, Nastaran Mohammadzadeh, Iraj Khalili, Neda Heredia, Raúl Jimenez Zoghi, Samaneh Boztug, Kaan Rezaei, Nima IDCases Case Report Patients with primary immunodeficiency disease (PID) are not only vulnerable to mycobacterial disease, but are also more likely to develop adverse events following BCG vaccination. These events can range from regional disease (BCGitis) to disseminated disease (BCGosis). Chronic granulomatous disease (CGD), which is characterized by impaired leukocyte phagocytic function, is one of the many inherited PIDs that increase the body’s susceptibility to recurrent bacterial and fungal infections. Here, we report a 6-year-old boy with no significant past medical history who presented with progressive lymphadenopathy six years after BCG vaccination. He was later diagnosed with CGD on further evaluation. Elsevier 2020-12-29 /pmc/articles/PMC7785948/ /pubmed/33425681 http://dx.doi.org/10.1016/j.idcr.2020.e01038 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Khalili, Nastaran
Mohammadzadeh, Iraj
Khalili, Neda
Heredia, Raúl Jimenez
Zoghi, Samaneh
Boztug, Kaan
Rezaei, Nima
BCGitis as the primary manifestation of chronic granulomatous disease
title BCGitis as the primary manifestation of chronic granulomatous disease
title_full BCGitis as the primary manifestation of chronic granulomatous disease
title_fullStr BCGitis as the primary manifestation of chronic granulomatous disease
title_full_unstemmed BCGitis as the primary manifestation of chronic granulomatous disease
title_short BCGitis as the primary manifestation of chronic granulomatous disease
title_sort bcgitis as the primary manifestation of chronic granulomatous disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785948/
https://www.ncbi.nlm.nih.gov/pubmed/33425681
http://dx.doi.org/10.1016/j.idcr.2020.e01038
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