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Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis

Ferroptosis is a newly discovered form of necrotic cell death characterized by its dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinson’s disease (PD), a major neurodegenerative...

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Autores principales: Wen, Shuheng, Aki, Toshihiko, Unuma, Kana, Uemura, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786020/
https://www.ncbi.nlm.nih.gov/pubmed/33424553
http://dx.doi.org/10.3389/fncel.2020.581191
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author Wen, Shuheng
Aki, Toshihiko
Unuma, Kana
Uemura, Koichi
author_facet Wen, Shuheng
Aki, Toshihiko
Unuma, Kana
Uemura, Koichi
author_sort Wen, Shuheng
collection PubMed
description Ferroptosis is a newly discovered form of necrotic cell death characterized by its dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinson’s disease (PD), a major neurodegenerative disease, has been indicated using animal models. Although PD is associated with both genetic and environmental factors, sporadic forms of PD account for more than 90% of total PD. Following the importance of environmental factors, various neurotoxins are used as chemical inducers of PD both in vivo and in vitro. In contrast to other neurodegenerative diseases such as Alzheimer’s and Huntington’s diseases (AD and HD), many of the characteristics of PD can be reproduced in vivo by the use of specific neurotoxins. Given the indication of ferroptosis in PD pathology, several studies have been conducted to examine whether ferroptosis plays role in the loss of dopaminergic neurons in PD. However, there are still few reports showing an authentic form of ferroptosis in neuronal cells during exposure to the neurotoxins used as PD inducers. In this review article, we summarize the history of the uses of chemicals to create PD models in vivo and in vitro. Besides, we also survey recent reports examining the possible involvement of ferroptosis in chemical models of PD.
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spelling pubmed-77860202021-01-07 Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis Wen, Shuheng Aki, Toshihiko Unuma, Kana Uemura, Koichi Front Cell Neurosci Cellular Neuroscience Ferroptosis is a newly discovered form of necrotic cell death characterized by its dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinson’s disease (PD), a major neurodegenerative disease, has been indicated using animal models. Although PD is associated with both genetic and environmental factors, sporadic forms of PD account for more than 90% of total PD. Following the importance of environmental factors, various neurotoxins are used as chemical inducers of PD both in vivo and in vitro. In contrast to other neurodegenerative diseases such as Alzheimer’s and Huntington’s diseases (AD and HD), many of the characteristics of PD can be reproduced in vivo by the use of specific neurotoxins. Given the indication of ferroptosis in PD pathology, several studies have been conducted to examine whether ferroptosis plays role in the loss of dopaminergic neurons in PD. However, there are still few reports showing an authentic form of ferroptosis in neuronal cells during exposure to the neurotoxins used as PD inducers. In this review article, we summarize the history of the uses of chemicals to create PD models in vivo and in vitro. Besides, we also survey recent reports examining the possible involvement of ferroptosis in chemical models of PD. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7786020/ /pubmed/33424553 http://dx.doi.org/10.3389/fncel.2020.581191 Text en Copyright © 2020 Wen, Aki, Unuma and Uemura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Wen, Shuheng
Aki, Toshihiko
Unuma, Kana
Uemura, Koichi
Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis
title Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis
title_full Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis
title_fullStr Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis
title_full_unstemmed Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis
title_short Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis
title_sort chemically induced models of parkinson’s disease: history and perspectives for the involvement of ferroptosis
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786020/
https://www.ncbi.nlm.nih.gov/pubmed/33424553
http://dx.doi.org/10.3389/fncel.2020.581191
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