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Intestinal Microbes in Autoimmune and Inflammatory Disease
Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflamm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786055/ https://www.ncbi.nlm.nih.gov/pubmed/33424846 http://dx.doi.org/10.3389/fimmu.2020.597966 |
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author | Wu, Wan-Jung H. Zegarra-Ruiz, Daniel F. Diehl, Gretchen E. |
author_facet | Wu, Wan-Jung H. Zegarra-Ruiz, Daniel F. Diehl, Gretchen E. |
author_sort | Wu, Wan-Jung H. |
collection | PubMed |
description | Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases. |
format | Online Article Text |
id | pubmed-7786055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77860552021-01-07 Intestinal Microbes in Autoimmune and Inflammatory Disease Wu, Wan-Jung H. Zegarra-Ruiz, Daniel F. Diehl, Gretchen E. Front Immunol Immunology Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7786055/ /pubmed/33424846 http://dx.doi.org/10.3389/fimmu.2020.597966 Text en Copyright © 2020 Wu, Zegarra-Ruiz and Diehl http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Wan-Jung H. Zegarra-Ruiz, Daniel F. Diehl, Gretchen E. Intestinal Microbes in Autoimmune and Inflammatory Disease |
title | Intestinal Microbes in Autoimmune and Inflammatory Disease |
title_full | Intestinal Microbes in Autoimmune and Inflammatory Disease |
title_fullStr | Intestinal Microbes in Autoimmune and Inflammatory Disease |
title_full_unstemmed | Intestinal Microbes in Autoimmune and Inflammatory Disease |
title_short | Intestinal Microbes in Autoimmune and Inflammatory Disease |
title_sort | intestinal microbes in autoimmune and inflammatory disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786055/ https://www.ncbi.nlm.nih.gov/pubmed/33424846 http://dx.doi.org/10.3389/fimmu.2020.597966 |
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