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An Additional Ca(2+) Binding Site Allosterically Controls TMEM16A Activation

Calcium (Ca(2+)) is the primary stimulus for transmembrane protein 16 (TMEM16) Ca(2+)-activated chloride channels and phospholipid scramblases, which regulate important physiological processes ranging from smooth muscle contraction to blood coagulation and tumor progression. Binding of intracellular...

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Detalles Bibliográficos
Autores principales: Le, Son C., Yang, Huanghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786149/
https://www.ncbi.nlm.nih.gov/pubmed/33378669
http://dx.doi.org/10.1016/j.celrep.2020.108570