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An Additional Ca(2+) Binding Site Allosterically Controls TMEM16A Activation
Calcium (Ca(2+)) is the primary stimulus for transmembrane protein 16 (TMEM16) Ca(2+)-activated chloride channels and phospholipid scramblases, which regulate important physiological processes ranging from smooth muscle contraction to blood coagulation and tumor progression. Binding of intracellular...
Autores principales: | Le, Son C., Yang, Huanghe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786149/ https://www.ncbi.nlm.nih.gov/pubmed/33378669 http://dx.doi.org/10.1016/j.celrep.2020.108570 |
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