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Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium

Research efforts in the twenty-first century have been paramount to the discovery and development of novel pharmacological treatments in a variety of diseases resulting in improved life expectancy. Yet, cardiac disease remains a leading cause of morbidity and mortality worldwide. Over time, there ha...

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Autores principales: Kumar, Vishnu K., Lackey, Atreju, Snyder, Jonathan, Karhadkar, Sunil, Rao, Ajay D., DiCarlo, Antonio, Sato, Priscila Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786191/
https://www.ncbi.nlm.nih.gov/pubmed/33425917
http://dx.doi.org/10.3389/fcell.2020.609241
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author Kumar, Vishnu K.
Lackey, Atreju
Snyder, Jonathan
Karhadkar, Sunil
Rao, Ajay D.
DiCarlo, Antonio
Sato, Priscila Y.
author_facet Kumar, Vishnu K.
Lackey, Atreju
Snyder, Jonathan
Karhadkar, Sunil
Rao, Ajay D.
DiCarlo, Antonio
Sato, Priscila Y.
author_sort Kumar, Vishnu K.
collection PubMed
description Research efforts in the twenty-first century have been paramount to the discovery and development of novel pharmacological treatments in a variety of diseases resulting in improved life expectancy. Yet, cardiac disease remains a leading cause of morbidity and mortality worldwide. Over time, there has been an expansion in conditions such as atrial fibrillation (AF) and heart failure (HF). Although past research has elucidated specific pathways that participate in the development of distinct cardiac pathologies, the exact mechanisms of action leading to disease remain to be fully characterized. Protein turnover and cellular bioenergetics are integral components of cardiac diseases, highlighting the importance of mitochondria and endoplasmic reticulum (ER) in driving cellular homeostasis. More specifically, the interactions between mitochondria and ER are crucial to calcium signaling, apoptosis induction, autophagy, and lipid biosynthesis. Here, we summarize mitochondrial and ER functions and physical interactions in healthy physiological states. We then transition to perturbations that occur in response to pathophysiological challenges and how this alters mitochondrial–ER and other intracellular organelle interactions. Finally, we discuss lifestyle interventions and innovative therapeutic targets that may be used to restore beneficial mitochondrial and ER interactions, thereby improving cardiac function.
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spelling pubmed-77861912021-01-07 Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium Kumar, Vishnu K. Lackey, Atreju Snyder, Jonathan Karhadkar, Sunil Rao, Ajay D. DiCarlo, Antonio Sato, Priscila Y. Front Cell Dev Biol Cell and Developmental Biology Research efforts in the twenty-first century have been paramount to the discovery and development of novel pharmacological treatments in a variety of diseases resulting in improved life expectancy. Yet, cardiac disease remains a leading cause of morbidity and mortality worldwide. Over time, there has been an expansion in conditions such as atrial fibrillation (AF) and heart failure (HF). Although past research has elucidated specific pathways that participate in the development of distinct cardiac pathologies, the exact mechanisms of action leading to disease remain to be fully characterized. Protein turnover and cellular bioenergetics are integral components of cardiac diseases, highlighting the importance of mitochondria and endoplasmic reticulum (ER) in driving cellular homeostasis. More specifically, the interactions between mitochondria and ER are crucial to calcium signaling, apoptosis induction, autophagy, and lipid biosynthesis. Here, we summarize mitochondrial and ER functions and physical interactions in healthy physiological states. We then transition to perturbations that occur in response to pathophysiological challenges and how this alters mitochondrial–ER and other intracellular organelle interactions. Finally, we discuss lifestyle interventions and innovative therapeutic targets that may be used to restore beneficial mitochondrial and ER interactions, thereby improving cardiac function. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7786191/ /pubmed/33425917 http://dx.doi.org/10.3389/fcell.2020.609241 Text en Copyright © 2020 Kumar, Lackey, Snyder, Karhadkar, Rao, DiCarlo and Sato. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Kumar, Vishnu K.
Lackey, Atreju
Snyder, Jonathan
Karhadkar, Sunil
Rao, Ajay D.
DiCarlo, Antonio
Sato, Priscila Y.
Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
title Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
title_full Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
title_fullStr Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
title_full_unstemmed Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
title_short Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
title_sort mitochondrial membrane intracellular communication in healthy and diseased myocardium
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786191/
https://www.ncbi.nlm.nih.gov/pubmed/33425917
http://dx.doi.org/10.3389/fcell.2020.609241
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