Importance of Block Randomization When Designing Proteomics Experiments

[Image: see text] Randomization is used in experimental design to reduce the prevalence of unanticipated confounders. Complete randomization can however create imbalanced designs, for example, grouping all samples of the same condition in the same batch. Block randomization is an approach that can p...

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Autores principales: Burger, Bram, Vaudel, Marc, Barsnes, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786377/
https://www.ncbi.nlm.nih.gov/pubmed/32969222
http://dx.doi.org/10.1021/acs.jproteome.0c00536
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author Burger, Bram
Vaudel, Marc
Barsnes, Harald
author_facet Burger, Bram
Vaudel, Marc
Barsnes, Harald
author_sort Burger, Bram
collection PubMed
description [Image: see text] Randomization is used in experimental design to reduce the prevalence of unanticipated confounders. Complete randomization can however create imbalanced designs, for example, grouping all samples of the same condition in the same batch. Block randomization is an approach that can prevent severe imbalances in sample allocation with respect to both known and unknown confounders. This feature provides the reader with an introduction to blocking and randomization, and insights into how to effectively organize samples during experimental design, with special considerations with respect to proteomics.
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spelling pubmed-77863772021-01-07 Importance of Block Randomization When Designing Proteomics Experiments Burger, Bram Vaudel, Marc Barsnes, Harald J Proteome Res [Image: see text] Randomization is used in experimental design to reduce the prevalence of unanticipated confounders. Complete randomization can however create imbalanced designs, for example, grouping all samples of the same condition in the same batch. Block randomization is an approach that can prevent severe imbalances in sample allocation with respect to both known and unknown confounders. This feature provides the reader with an introduction to blocking and randomization, and insights into how to effectively organize samples during experimental design, with special considerations with respect to proteomics. American Chemical Society 2020-09-21 2021-01-01 /pmc/articles/PMC7786377/ /pubmed/32969222 http://dx.doi.org/10.1021/acs.jproteome.0c00536 Text en This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Burger, Bram
Vaudel, Marc
Barsnes, Harald
Importance of Block Randomization When Designing Proteomics Experiments
title Importance of Block Randomization When Designing Proteomics Experiments
title_full Importance of Block Randomization When Designing Proteomics Experiments
title_fullStr Importance of Block Randomization When Designing Proteomics Experiments
title_full_unstemmed Importance of Block Randomization When Designing Proteomics Experiments
title_short Importance of Block Randomization When Designing Proteomics Experiments
title_sort importance of block randomization when designing proteomics experiments
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786377/
https://www.ncbi.nlm.nih.gov/pubmed/32969222
http://dx.doi.org/10.1021/acs.jproteome.0c00536
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