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Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons

BACKGROUND: OnabotulinumtoxinA and agents that block calcitonin gene‒receptor peptide action have both been found to have anti-migraine effects, but they inhibit different populations of meningeal nociceptors. We therefore tested the effects of combined treatment with onabotulinumtoxinA and the calc...

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Detalles Bibliográficos
Autores principales: Melo-Carrillo, Agustin, Strassman, Andrew M, Schain, Aaron J, Adams, Aubrey Manack, Brin, Mitchell F, Burstein, Rami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786391/
https://www.ncbi.nlm.nih.gov/pubmed/33200944
http://dx.doi.org/10.1177/0333102420970507