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The Role(s) of Eicosanoids and Exosomes in Human Parturition

The roles that eicosanoids play during pregnancy and parturition are crucial to a successful outcome. A better understanding of the regulation of eicosanoid production and the roles played by the various end products during pregnancy and parturition has led to our view that accurate measurements of...

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Autores principales: Mosaad, Eman, Peiris, Hassendrini N., Holland, Olivia, Morean Garcia, Isabella, Mitchell, Murray D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786405/
https://www.ncbi.nlm.nih.gov/pubmed/33424622
http://dx.doi.org/10.3389/fphys.2020.594313
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author Mosaad, Eman
Peiris, Hassendrini N.
Holland, Olivia
Morean Garcia, Isabella
Mitchell, Murray D.
author_facet Mosaad, Eman
Peiris, Hassendrini N.
Holland, Olivia
Morean Garcia, Isabella
Mitchell, Murray D.
author_sort Mosaad, Eman
collection PubMed
description The roles that eicosanoids play during pregnancy and parturition are crucial to a successful outcome. A better understanding of the regulation of eicosanoid production and the roles played by the various end products during pregnancy and parturition has led to our view that accurate measurements of a panel of those end products has exciting potential as diagnostics and prognostics of preterm labor and delivery. Exosomes and their contents represent an exciting new area for research of movement of key biological factors circulating between tissues and organs akin to a parallel endocrine system but involving key intracellular mediators. Eicosanoids and enzymes regulating their biosynthesis and metabolism as well as regulatory microRNAs have been identified within exosomes. In this review, the regulation of eicosanoid production, abundance and actions during pregnancy will be explored. Additionally, the functional significance of placental exosomes will be discussed.
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spelling pubmed-77864052021-01-07 The Role(s) of Eicosanoids and Exosomes in Human Parturition Mosaad, Eman Peiris, Hassendrini N. Holland, Olivia Morean Garcia, Isabella Mitchell, Murray D. Front Physiol Physiology The roles that eicosanoids play during pregnancy and parturition are crucial to a successful outcome. A better understanding of the regulation of eicosanoid production and the roles played by the various end products during pregnancy and parturition has led to our view that accurate measurements of a panel of those end products has exciting potential as diagnostics and prognostics of preterm labor and delivery. Exosomes and their contents represent an exciting new area for research of movement of key biological factors circulating between tissues and organs akin to a parallel endocrine system but involving key intracellular mediators. Eicosanoids and enzymes regulating their biosynthesis and metabolism as well as regulatory microRNAs have been identified within exosomes. In this review, the regulation of eicosanoid production, abundance and actions during pregnancy will be explored. Additionally, the functional significance of placental exosomes will be discussed. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7786405/ /pubmed/33424622 http://dx.doi.org/10.3389/fphys.2020.594313 Text en Copyright © 2020 Mosaad, Peiris, Holland, Morean Garcia and Mitchell. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Mosaad, Eman
Peiris, Hassendrini N.
Holland, Olivia
Morean Garcia, Isabella
Mitchell, Murray D.
The Role(s) of Eicosanoids and Exosomes in Human Parturition
title The Role(s) of Eicosanoids and Exosomes in Human Parturition
title_full The Role(s) of Eicosanoids and Exosomes in Human Parturition
title_fullStr The Role(s) of Eicosanoids and Exosomes in Human Parturition
title_full_unstemmed The Role(s) of Eicosanoids and Exosomes in Human Parturition
title_short The Role(s) of Eicosanoids and Exosomes in Human Parturition
title_sort role(s) of eicosanoids and exosomes in human parturition
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786405/
https://www.ncbi.nlm.nih.gov/pubmed/33424622
http://dx.doi.org/10.3389/fphys.2020.594313
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