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Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo

BACKGROUND: The low extracellular pH (pH(e)) of tumors resulting from glycolytic metabolism is a stress factor for the cells independent from concomitant hypoxia. The aim of the study was to analyze the impact of acidic pH(e) on gene expression on mRNA and protein level in two experimental tumor lin...

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Detalles Bibliográficos
Autores principales:	Rauschner, Mandy, Lange, Luisa, Hüsing, Thea, Reime, Sarah, Nolze, Alexander, Maschek, Marcel, Thews, Oliver, Riemann, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786478/ https://www.ncbi.nlm.nih.gov/pubmed/33407762 http://dx.doi.org/10.1186/s13046-020-01815-4

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