Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [(11)C]UCB-J

BACKGROUND: Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clinical severity or neurodegeneration—at least in the dementia stag...

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Detalles Bibliográficos
Autores principales: O’Dell, Ryan S., Mecca, Adam P., Chen, Ming-Kai, Naganawa, Mika, Toyonaga, Takuya, Lu, Yihuan, Godek, Tyler A., Harris, Joanna E., Bartlett, Hugh H., Banks, Emmie R., Kominek, Victoria L., Zhao, Wenzhen, Nabulsi, Nabeel B., Ropchan, Jim, Ye, Yunpeng, Vander Wyk, Brent C., Huang, Yiyun, Arnsten, Amy F. T., Carson, Richard E., van Dyck, Christopher H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786921/
https://www.ncbi.nlm.nih.gov/pubmed/33402201
http://dx.doi.org/10.1186/s13195-020-00742-y

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