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The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
BACKGROUND: Insulin resistance is suggested to have negative effects on cognition; however, results from large population studies are lacking. In this study, the potential relationships between the triglyceride glucose (TyG) index, a simple surrogate marker of insulin resistance, and dementia were e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786939/ https://www.ncbi.nlm.nih.gov/pubmed/33402193 http://dx.doi.org/10.1186/s13195-020-00758-4 |
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author | Hong, Sangmo Han, Kyungdo Park, Cheol-Young |
author_facet | Hong, Sangmo Han, Kyungdo Park, Cheol-Young |
author_sort | Hong, Sangmo |
collection | PubMed |
description | BACKGROUND: Insulin resistance is suggested to have negative effects on cognition; however, results from large population studies are lacking. In this study, the potential relationships between the triglyceride glucose (TyG) index, a simple surrogate marker of insulin resistance, and dementia were evaluated using a large-scale population dataset. METHODS: This was a retrospective, observational, cohort study using data from the National Health Information Database from 2009 to 2015 and included 5,586,048 participants 40 years age or older. The TyG index was used as a measure of insulin resistance, and participants were divided into quartiles based on TyG index. The incidence of dementia was assessed using hazard ratios (HRs) estimated with Cox proportional hazard modeling. RESULTS: During a median follow-up of 7.21 years, dementia was diagnosed in 142,714 (2.55%) participants. Alzheimer’s disease (AD) and vascular dementia (VD) were diagnosed in 74.3% and 12.5% of the participants. Multivariate-adjusted HRs for patients in the TyG index 4th quartile were higher for dementia (HRs = 1.14; 95% confidence interval [CI] 1.12–1.16), AD (HRs = 1.12; 95% CI 1.09–1.14), and VD (HRs = 1.18; 95% CI 1.12–1.23) compared with the 1st quartile of TyG index; however, this had a small effect size (Cohen’s d = 0.10, 0.08, and 0.13, respectively). These effects were independent of age, sex, smoking status, physical activity, body mass index, systolic blood pressure, and total cholesterol. CONCLUSION: In this large population study, TyG index was associated with an increased risk of dementia, including AD and VD, that was independent of traditional cardiovascular risk factors, although the effect size of the TyG index was small. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-020-00758-4. |
format | Online Article Text |
id | pubmed-7786939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77869392021-01-07 The insulin resistance by triglyceride glucose index and risk for dementia: population-based study Hong, Sangmo Han, Kyungdo Park, Cheol-Young Alzheimers Res Ther Research BACKGROUND: Insulin resistance is suggested to have negative effects on cognition; however, results from large population studies are lacking. In this study, the potential relationships between the triglyceride glucose (TyG) index, a simple surrogate marker of insulin resistance, and dementia were evaluated using a large-scale population dataset. METHODS: This was a retrospective, observational, cohort study using data from the National Health Information Database from 2009 to 2015 and included 5,586,048 participants 40 years age or older. The TyG index was used as a measure of insulin resistance, and participants were divided into quartiles based on TyG index. The incidence of dementia was assessed using hazard ratios (HRs) estimated with Cox proportional hazard modeling. RESULTS: During a median follow-up of 7.21 years, dementia was diagnosed in 142,714 (2.55%) participants. Alzheimer’s disease (AD) and vascular dementia (VD) were diagnosed in 74.3% and 12.5% of the participants. Multivariate-adjusted HRs for patients in the TyG index 4th quartile were higher for dementia (HRs = 1.14; 95% confidence interval [CI] 1.12–1.16), AD (HRs = 1.12; 95% CI 1.09–1.14), and VD (HRs = 1.18; 95% CI 1.12–1.23) compared with the 1st quartile of TyG index; however, this had a small effect size (Cohen’s d = 0.10, 0.08, and 0.13, respectively). These effects were independent of age, sex, smoking status, physical activity, body mass index, systolic blood pressure, and total cholesterol. CONCLUSION: In this large population study, TyG index was associated with an increased risk of dementia, including AD and VD, that was independent of traditional cardiovascular risk factors, although the effect size of the TyG index was small. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-020-00758-4. BioMed Central 2021-01-05 /pmc/articles/PMC7786939/ /pubmed/33402193 http://dx.doi.org/10.1186/s13195-020-00758-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hong, Sangmo Han, Kyungdo Park, Cheol-Young The insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
title | The insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
title_full | The insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
title_fullStr | The insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
title_full_unstemmed | The insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
title_short | The insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
title_sort | insulin resistance by triglyceride glucose index and risk for dementia: population-based study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786939/ https://www.ncbi.nlm.nih.gov/pubmed/33402193 http://dx.doi.org/10.1186/s13195-020-00758-4 |
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