Role of long non-coding RNA H19 in therapy resistance of digestive system cancers

Digestive system cancers are associated with high morbidity and mortality. Chemotherapy and radiotherapy are the main treatment modalities for these cancers. However, the development of therapy resistance leads to high rates of tumor recurrence and metastasis, resulting in dismal prognosis. Long non...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jingting, Ma, Xiao, Si, Hai, Ma, Zhongjun, Ma, Yan, Wang, Jing, Cao, Bangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786989/
https://www.ncbi.nlm.nih.gov/pubmed/33402118
http://dx.doi.org/10.1186/s10020-020-00255-2
_version_ 1783632740054204416
author Wang, Jingting
Ma, Xiao
Si, Hai
Ma, Zhongjun
Ma, Yan
Wang, Jing
Cao, Bangwei
author_facet Wang, Jingting
Ma, Xiao
Si, Hai
Ma, Zhongjun
Ma, Yan
Wang, Jing
Cao, Bangwei
author_sort Wang, Jingting
collection PubMed
description Digestive system cancers are associated with high morbidity and mortality. Chemotherapy and radiotherapy are the main treatment modalities for these cancers. However, the development of therapy resistance leads to high rates of tumor recurrence and metastasis, resulting in dismal prognosis. Long non-coding RNA (LncRNA) H19, one of the most intriguing non-coding RNAs, has been shown to play a key role in the development and therapy resistance of various digestive system cancers (including hepatocellular carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma, esophageal carcinoma, gastric cancer, and biliary system cancer) by regulating the abnormal expression of genes. In this review, we discuss the potential mechanisms of LncRNA H19 related therapy resistance in the context of digestive system cancers. LncRNA H19 is a potential novel therapeutic target for amelioration of cancer therapy resistance.
format Online
Article
Text
id pubmed-7786989
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-77869892021-01-06 Role of long non-coding RNA H19 in therapy resistance of digestive system cancers Wang, Jingting Ma, Xiao Si, Hai Ma, Zhongjun Ma, Yan Wang, Jing Cao, Bangwei Mol Med Review Digestive system cancers are associated with high morbidity and mortality. Chemotherapy and radiotherapy are the main treatment modalities for these cancers. However, the development of therapy resistance leads to high rates of tumor recurrence and metastasis, resulting in dismal prognosis. Long non-coding RNA (LncRNA) H19, one of the most intriguing non-coding RNAs, has been shown to play a key role in the development and therapy resistance of various digestive system cancers (including hepatocellular carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma, esophageal carcinoma, gastric cancer, and biliary system cancer) by regulating the abnormal expression of genes. In this review, we discuss the potential mechanisms of LncRNA H19 related therapy resistance in the context of digestive system cancers. LncRNA H19 is a potential novel therapeutic target for amelioration of cancer therapy resistance. BioMed Central 2021-01-05 /pmc/articles/PMC7786989/ /pubmed/33402118 http://dx.doi.org/10.1186/s10020-020-00255-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Wang, Jingting
Ma, Xiao
Si, Hai
Ma, Zhongjun
Ma, Yan
Wang, Jing
Cao, Bangwei
Role of long non-coding RNA H19 in therapy resistance of digestive system cancers
title Role of long non-coding RNA H19 in therapy resistance of digestive system cancers
title_full Role of long non-coding RNA H19 in therapy resistance of digestive system cancers
title_fullStr Role of long non-coding RNA H19 in therapy resistance of digestive system cancers
title_full_unstemmed Role of long non-coding RNA H19 in therapy resistance of digestive system cancers
title_short Role of long non-coding RNA H19 in therapy resistance of digestive system cancers
title_sort role of long non-coding rna h19 in therapy resistance of digestive system cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786989/
https://www.ncbi.nlm.nih.gov/pubmed/33402118
http://dx.doi.org/10.1186/s10020-020-00255-2
work_keys_str_mv AT wangjingting roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers
AT maxiao roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers
AT sihai roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers
AT mazhongjun roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers
AT mayan roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers
AT wangjing roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers
AT caobangwei roleoflongnoncodingrnah19intherapyresistanceofdigestivesystemcancers

Ejemplares similares