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Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study

BACKGROUND: Like other complex diseases including drug addiction, genetic factors can interfere with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were examined for an association with drug addiction among Jordanian males. METHODS: The study involved 498 addicts, in additi...

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Autores principales: AL-Eitan, Laith N., Rababa’h, Doaa M., Alghamdi, Mansour A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786995/
https://www.ncbi.nlm.nih.gov/pubmed/33402148
http://dx.doi.org/10.1186/s12888-020-03006-z
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author AL-Eitan, Laith N.
Rababa’h, Doaa M.
Alghamdi, Mansour A.
author_facet AL-Eitan, Laith N.
Rababa’h, Doaa M.
Alghamdi, Mansour A.
author_sort AL-Eitan, Laith N.
collection PubMed
description BACKGROUND: Like other complex diseases including drug addiction, genetic factors can interfere with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were examined for an association with drug addiction among Jordanian males. METHODS: The study involved 498 addicts, in addition to 496 healthy controls and all from Arab descent. RESULTS: The findings in this study showed that rs1799971 of the OPRM1 gene was in association with drug addiction for both alleles and genotypes with P-values = 0.002 and 0.01, respectively. In addition, a significant association between the dominant model (A/A vs G/A-G/G) of rs1799971 (OPRM1) and drug addiction (P-value = 0.003, OR = 1.59 (1.17–2.15)) was detected. Moreover, a genetic haplotype (AGGGCGACCCC) of theOPRM1 gene revealed a significant association with drug addiction (P-value = 0.01, OR = 1.56 (1.15–2.12)). We also found that the age of addicts, smoking, and marital status with genetic variants within OPRM1, OPRD1, and OPRK1 genes may be implicated in drug addiction risk. CONCLUSION: We propose that rs1799971 of the OPRM1gene is a genetic risk factor for drug addiction among Jordanian males. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-020-03006-z.
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spelling pubmed-77869952021-01-07 Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study AL-Eitan, Laith N. Rababa’h, Doaa M. Alghamdi, Mansour A. BMC Psychiatry Research Article BACKGROUND: Like other complex diseases including drug addiction, genetic factors can interfere with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were examined for an association with drug addiction among Jordanian males. METHODS: The study involved 498 addicts, in addition to 496 healthy controls and all from Arab descent. RESULTS: The findings in this study showed that rs1799971 of the OPRM1 gene was in association with drug addiction for both alleles and genotypes with P-values = 0.002 and 0.01, respectively. In addition, a significant association between the dominant model (A/A vs G/A-G/G) of rs1799971 (OPRM1) and drug addiction (P-value = 0.003, OR = 1.59 (1.17–2.15)) was detected. Moreover, a genetic haplotype (AGGGCGACCCC) of theOPRM1 gene revealed a significant association with drug addiction (P-value = 0.01, OR = 1.56 (1.15–2.12)). We also found that the age of addicts, smoking, and marital status with genetic variants within OPRM1, OPRD1, and OPRK1 genes may be implicated in drug addiction risk. CONCLUSION: We propose that rs1799971 of the OPRM1gene is a genetic risk factor for drug addiction among Jordanian males. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-020-03006-z. BioMed Central 2021-01-05 /pmc/articles/PMC7786995/ /pubmed/33402148 http://dx.doi.org/10.1186/s12888-020-03006-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
AL-Eitan, Laith N.
Rababa’h, Doaa M.
Alghamdi, Mansour A.
Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study
title Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study
title_full Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study
title_fullStr Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study
title_full_unstemmed Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study
title_short Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study
title_sort genetic susceptibility of opioid receptor genes polymorphism to drug addiction: a candidate-gene association study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786995/
https://www.ncbi.nlm.nih.gov/pubmed/33402148
http://dx.doi.org/10.1186/s12888-020-03006-z
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