Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism

PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the pl...

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Autores principales: Huet, Fabien, Fauconnier, Jérémy, Legall, Marion, Sicard, Pierre, Lozza, Catherine, Lacampagne, Alain, Roubille, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787178/
https://www.ncbi.nlm.nih.gov/pubmed/33437519
http://dx.doi.org/10.2144/fsoa-2020-0151
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author Huet, Fabien
Fauconnier, Jérémy
Legall, Marion
Sicard, Pierre
Lozza, Catherine
Lacampagne, Alain
Roubille, François
author_facet Huet, Fabien
Fauconnier, Jérémy
Legall, Marion
Sicard, Pierre
Lozza, Catherine
Lacampagne, Alain
Roubille, François
author_sort Huet, Fabien
collection PubMed
description PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion. RESULTS: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70). CONCLUSION: These results suggest promising protective pathway of colchicine after AMI.
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spelling pubmed-77871782021-01-11 Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism Huet, Fabien Fauconnier, Jérémy Legall, Marion Sicard, Pierre Lozza, Catherine Lacampagne, Alain Roubille, François Future Sci OA Short Communication PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion. RESULTS: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70). CONCLUSION: These results suggest promising protective pathway of colchicine after AMI. Future Science Ltd 2020-11-23 /pmc/articles/PMC7787178/ /pubmed/33437519 http://dx.doi.org/10.2144/fsoa-2020-0151 Text en © 2020 Fabien Huet This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Short Communication
Huet, Fabien
Fauconnier, Jérémy
Legall, Marion
Sicard, Pierre
Lozza, Catherine
Lacampagne, Alain
Roubille, François
Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
title Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
title_full Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
title_fullStr Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
title_full_unstemmed Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
title_short Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
title_sort low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787178/
https://www.ncbi.nlm.nih.gov/pubmed/33437519
http://dx.doi.org/10.2144/fsoa-2020-0151
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