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Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo

The E3 ubiquitin ligase Rad18 promotes a damage-tolerant and error-prone mode of DNA replication termed trans-lesion synthesis that is pathologically activated in cancer. However, the impact of vertebrate Rad18 on cancer genomes is not known. To determine how Rad18 affects mutagenesis in vivo, we ha...

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Detalles Bibliográficos
Autores principales:	Lou, Jitong, Yang, Yang, Gu, Qisheng, Price, Brandon A, Qiu, Yuheng, Fedoriw, Yuri, Desai, Siddhi, Mose, Lisle E, Chen, Brian, Tateishi, Satoshi, Parker, Joel S, Vaziri, Cyrus, Wu, Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Cancer Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787264/ https://www.ncbi.nlm.nih.gov/pubmed/33447826 http://dx.doi.org/10.1093/narcan/zcaa037

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