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Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA damage response

Identifying attributes that distinguish pre-malignant from senescent cells provides opportunities for targeted disease eradication and revival of anti-tumour immunity. We modelled a telomere-driven crisis in four human fibroblast lines, sampling at multiple time points to delineate genomic rearrange...

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Detalles Bibliográficos
Autores principales:	Liddiard, Kate, Grimstead, Julia W, Cleal, Kez, Evans, Anna, Baird, Duncan M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787266/ https://www.ncbi.nlm.nih.gov/pubmed/33447828 http://dx.doi.org/10.1093/narcan/zcaa044

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