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Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement
Split-thickness skin graft has been the standard in the coverage of large full-thickness skin defects. However, donor sites can be associated with significant pain and scarring. Further, the recipient sites frequently lack some basic skin functions, such as temperature regulation, uniform texture, a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787311/ https://www.ncbi.nlm.nih.gov/pubmed/33425612 http://dx.doi.org/10.1097/GOX.0000000000003304 |
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author | Cooper, Laura Gronet, Edward Carlsson, Anders Chan, Rodney |
author_facet | Cooper, Laura Gronet, Edward Carlsson, Anders Chan, Rodney |
author_sort | Cooper, Laura |
collection | PubMed |
description | Split-thickness skin graft has been the standard in the coverage of large full-thickness skin defects. However, donor sites can be associated with significant pain and scarring. Further, the recipient sites frequently lack some basic skin functions, such as temperature regulation, uniform texture, appropriate color, normal pliability, elasticity, and lubrication. Full-thickness skin grafts, while able to more adequately recapitulate skin function, have even greater donor site requirements. Implantation of full-thickness skin micro-columns is a relatively novel concept in which the skin is harvested orthogonally rather than tangentially. These micro-columns contain elements of full-thickness skin grafts, including reticular dermal fibroblasts, hair follicles, skin adnexa, and adipose tissue—all elements that contribute to skin function. Notably, it has been shown that the diameter of the skin micro-columns determine donor site morbidity; however, in most cases, full-thickness skin micro-column harvest results in a trivial donor site far less invasive or morbid than a traditional full-thickness skin graft or split-thickness skin graft harvest. Here, we present 2 cases in which full-thickness skin micro-columns were harvested and implanted into a bilayer dermal regeneration matrix (Integra) to achieve durable single-stage skin replacement with practically no donor site morbidity. |
format | Online Article Text |
id | pubmed-7787311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-77873112021-01-07 Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement Cooper, Laura Gronet, Edward Carlsson, Anders Chan, Rodney Plast Reconstr Surg Glob Open Reconstructive Split-thickness skin graft has been the standard in the coverage of large full-thickness skin defects. However, donor sites can be associated with significant pain and scarring. Further, the recipient sites frequently lack some basic skin functions, such as temperature regulation, uniform texture, appropriate color, normal pliability, elasticity, and lubrication. Full-thickness skin grafts, while able to more adequately recapitulate skin function, have even greater donor site requirements. Implantation of full-thickness skin micro-columns is a relatively novel concept in which the skin is harvested orthogonally rather than tangentially. These micro-columns contain elements of full-thickness skin grafts, including reticular dermal fibroblasts, hair follicles, skin adnexa, and adipose tissue—all elements that contribute to skin function. Notably, it has been shown that the diameter of the skin micro-columns determine donor site morbidity; however, in most cases, full-thickness skin micro-column harvest results in a trivial donor site far less invasive or morbid than a traditional full-thickness skin graft or split-thickness skin graft harvest. Here, we present 2 cases in which full-thickness skin micro-columns were harvested and implanted into a bilayer dermal regeneration matrix (Integra) to achieve durable single-stage skin replacement with practically no donor site morbidity. Lippincott Williams & Wilkins 2020-12-18 /pmc/articles/PMC7787311/ /pubmed/33425612 http://dx.doi.org/10.1097/GOX.0000000000003304 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Reconstructive Cooper, Laura Gronet, Edward Carlsson, Anders Chan, Rodney Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement |
title | Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement |
title_full | Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement |
title_fullStr | Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement |
title_full_unstemmed | Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement |
title_short | Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for “Donor-free” Skin Replacement |
title_sort | full-thickness skin micro-columns within a dermal matrix: a novel method for “donor-free” skin replacement |
topic | Reconstructive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787311/ https://www.ncbi.nlm.nih.gov/pubmed/33425612 http://dx.doi.org/10.1097/GOX.0000000000003304 |
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