Cargando…

Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases

Pancreatic cancer (PC) rate is increasing in the U.S. The use of prescription and illicit opioids has continued to rise nationally in recent years as well. Opioids have been shown to have a deleterious effect on multiple types of cancer with recent data suggesting opium use as a risk factor for PC....

Descripción completa

Detalles Bibliográficos
Autores principales: Barlass, Usman, Deshmukh, Ameya, Beck, Todd, Bishehsari, Faraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787381/
https://www.ncbi.nlm.nih.gov/pubmed/33406096
http://dx.doi.org/10.1371/journal.pone.0244285
_version_ 1783632812204621824
author Barlass, Usman
Deshmukh, Ameya
Beck, Todd
Bishehsari, Faraz
author_facet Barlass, Usman
Deshmukh, Ameya
Beck, Todd
Bishehsari, Faraz
author_sort Barlass, Usman
collection PubMed
description Pancreatic cancer (PC) rate is increasing in the U.S. The use of prescription and illicit opioids has continued to rise nationally in recent years as well. Opioids have been shown to have a deleterious effect on multiple types of cancer with recent data suggesting opium use as a risk factor for PC. Using national databases, we tested whether opioid usage pattern over time could explain the state and national-based variations in PC rates in the U.S. Opioid death rate (as a surrogate for prescription and illicit opioid use) was extracted from the CDCs Wonder online data through the Vital Statistics Cooperative Program. Incidence of pancreatic cancer was retrieved from the online CDCs data base gathered from the U.S. Cancer Statistics Working Group. Prevalence of obesity, tobacco and alcohol use was collected from Behavioral risk factor surveillance system. Mixed-effects regression models were used to test the association between levels of PC rate and opioid death/use rates during the years 1999–2016. A rise in PC was seen over time at the national and state levels. Similarly, the opioid death rates increased over time. Among other potential PC risk factors, only obesity prevalence showed an increase during the study period. A state’s opioid death rate at 4 years prior significantly predicted initial incidence of PC (β = 0.1848, p<0.0001) and had a significant effect on the estimated annual change in the rate of PC (β = -.0193,p<0.0001). Opioid use may be an un-identified risk factor contributing to the increasing incidence of PC in the U.S. These novel findings need to be verified by population-based studies.
format Online
Article
Text
id pubmed-7787381
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-77873812021-01-13 Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases Barlass, Usman Deshmukh, Ameya Beck, Todd Bishehsari, Faraz PLoS One Research Article Pancreatic cancer (PC) rate is increasing in the U.S. The use of prescription and illicit opioids has continued to rise nationally in recent years as well. Opioids have been shown to have a deleterious effect on multiple types of cancer with recent data suggesting opium use as a risk factor for PC. Using national databases, we tested whether opioid usage pattern over time could explain the state and national-based variations in PC rates in the U.S. Opioid death rate (as a surrogate for prescription and illicit opioid use) was extracted from the CDCs Wonder online data through the Vital Statistics Cooperative Program. Incidence of pancreatic cancer was retrieved from the online CDCs data base gathered from the U.S. Cancer Statistics Working Group. Prevalence of obesity, tobacco and alcohol use was collected from Behavioral risk factor surveillance system. Mixed-effects regression models were used to test the association between levels of PC rate and opioid death/use rates during the years 1999–2016. A rise in PC was seen over time at the national and state levels. Similarly, the opioid death rates increased over time. Among other potential PC risk factors, only obesity prevalence showed an increase during the study period. A state’s opioid death rate at 4 years prior significantly predicted initial incidence of PC (β = 0.1848, p<0.0001) and had a significant effect on the estimated annual change in the rate of PC (β = -.0193,p<0.0001). Opioid use may be an un-identified risk factor contributing to the increasing incidence of PC in the U.S. These novel findings need to be verified by population-based studies. Public Library of Science 2021-01-06 /pmc/articles/PMC7787381/ /pubmed/33406096 http://dx.doi.org/10.1371/journal.pone.0244285 Text en © 2021 Barlass et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Barlass, Usman
Deshmukh, Ameya
Beck, Todd
Bishehsari, Faraz
Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases
title Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases
title_full Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases
title_fullStr Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases
title_full_unstemmed Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases
title_short Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases
title_sort opioid use as a potential risk factor for pancreatic cancer in the united states: an analysis of state and national level databases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787381/
https://www.ncbi.nlm.nih.gov/pubmed/33406096
http://dx.doi.org/10.1371/journal.pone.0244285
work_keys_str_mv AT barlassusman opioiduseasapotentialriskfactorforpancreaticcancerintheunitedstatesananalysisofstateandnationalleveldatabases
AT deshmukhameya opioiduseasapotentialriskfactorforpancreaticcancerintheunitedstatesananalysisofstateandnationalleveldatabases
AT becktodd opioiduseasapotentialriskfactorforpancreaticcancerintheunitedstatesananalysisofstateandnationalleveldatabases
AT bishehsarifaraz opioiduseasapotentialriskfactorforpancreaticcancerintheunitedstatesananalysisofstateandnationalleveldatabases