Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

Alzheimer’s disease (AD), the most common form of dementia, is recognized as a heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we interrogate the molecular heterogeneity of AD by analyzing 1543 transcriptomes across five brain regions in two AD cohorts using an integra...

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Detalles Bibliográficos
Autores principales: Neff, Ryan A., Wang, Minghui, Vatansever, Sezen, Guo, Lei, Ming, Chen, Wang, Qian, Wang, Erming, Horgusluoglu-Moloch, Emrin, Song, Won-min, Li, Aiqun, Castranio, Emilie L., TCW, Julia, Ho, Lap, Goate, Alison, Fossati, Valentina, Noggle, Scott, Gandy, Sam, Ehrlich, Michelle E., Katsel, Pavel, Schadt, Eric, Cai, Dongming, Brennand, Kristen J., Haroutunian, Vahram, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787497/
https://www.ncbi.nlm.nih.gov/pubmed/33523961
http://dx.doi.org/10.1126/sciadv.abb5398

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