A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several stu...

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Autores principales: Adak, Sanjucta, Magdalene, Damaris, Deshmukh, Saurabh, Das, Dipankar, Jaganathan, Bithiah Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787584/
https://www.ncbi.nlm.nih.gov/pubmed/33410097
http://dx.doi.org/10.1007/s12015-020-10090-x
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author Adak, Sanjucta
Magdalene, Damaris
Deshmukh, Saurabh
Das, Dipankar
Jaganathan, Bithiah Grace
author_facet Adak, Sanjucta
Magdalene, Damaris
Deshmukh, Saurabh
Das, Dipankar
Jaganathan, Bithiah Grace
author_sort Adak, Sanjucta
collection PubMed
description Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases. [Image: see text]
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spelling pubmed-77875842021-01-07 A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases Adak, Sanjucta Magdalene, Damaris Deshmukh, Saurabh Das, Dipankar Jaganathan, Bithiah Grace Stem Cell Rev Rep Article Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases. [Image: see text] Springer US 2021-01-06 2021 /pmc/articles/PMC7787584/ /pubmed/33410097 http://dx.doi.org/10.1007/s12015-020-10090-x Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Adak, Sanjucta
Magdalene, Damaris
Deshmukh, Saurabh
Das, Dipankar
Jaganathan, Bithiah Grace
A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
title A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
title_full A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
title_fullStr A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
title_full_unstemmed A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
title_short A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
title_sort review on mesenchymal stem cells for treatment of retinal diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787584/
https://www.ncbi.nlm.nih.gov/pubmed/33410097
http://dx.doi.org/10.1007/s12015-020-10090-x
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