Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

We demonstrate how RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and thereby determine nematode sex. FOX-1, an RNA recognition motif protein, triggers hermaphrodite development in XX embryos by causing non-productive alternative pre-mRNA...

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Detalles Bibliográficos
Autores principales: Farboud, Behnom, Novak, Catherine S, Nicoll, Monique, Quiogue, Alyssa, Meyer, Barbara J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787662/
https://www.ncbi.nlm.nih.gov/pubmed/33372658
http://dx.doi.org/10.7554/eLife.62963

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