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Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection
The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All hospitalized adult patients with a diagnosis of SAR...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787698/ https://www.ncbi.nlm.nih.gov/pubmed/33409832 http://dx.doi.org/10.1007/s10096-020-04150-w |
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author | de la Calle, Cristina Lalueza, Antonio Mancheño-Losa, Mikel Maestro-de la Calle, Guillermo Lora-Tamayo, Jaime Arrieta, Estibaliz García-Reyne, Ana Losada, Irene de Miguel, Borja Díaz-Simón, Raquel López-Medrano, Francisco Fernández-Ruiz, Mario Carretero, Octavio San Juan, Rafael Aguado, José María Lumbreras, Carlos |
author_facet | de la Calle, Cristina Lalueza, Antonio Mancheño-Losa, Mikel Maestro-de la Calle, Guillermo Lora-Tamayo, Jaime Arrieta, Estibaliz García-Reyne, Ana Losada, Irene de Miguel, Borja Díaz-Simón, Raquel López-Medrano, Francisco Fernández-Ruiz, Mario Carretero, Octavio San Juan, Rafael Aguado, José María Lumbreras, Carlos |
author_sort | de la Calle, Cristina |
collection | PubMed |
description | The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All hospitalized adult patients with a diagnosis of SARS-CoV-2 infection by rRT-PCR performed on a nasopharingeal sample from March 1 to March 18 in our institution were included. The study population was divided according to the Ct value obtained upon admission in patients with high viral load (Ct < 25), intermediate viral load (Ct: 25–30) and low viral load (Ct > 30). Demographic, clinical and laboratory variables of the different groups were analyzed to assess the influence of viral load on the development of respiratory failure during admission. Overall, 455 sequential patients were included. The median Ct value was 28 (IQR: 24–32). One hundred and thirty patients (28.6%) had a high viral load, 175 (38.5%) an intermediate viral load and 150 (33%) a low viral load. Advanced age, male sex, presence of cardiovascular disease and laboratory markers such as lactate dehydrogenase, lymphocyte count and C-reactive protein, as well as a high viral load on admission, were predictive of respiratory failure. A Ct value < 25 was associated with a higher risk of respiratory failure during admission (OR: 2.99, 95%IC: 1.57–5.69). SARS-CoV-2 viral load, measured through the Ct value on admission, is a valuable tool to predict the development of respiratory failure in COVID-19 inpatients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04150-w. |
format | Online Article Text |
id | pubmed-7787698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-77876982021-01-07 Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection de la Calle, Cristina Lalueza, Antonio Mancheño-Losa, Mikel Maestro-de la Calle, Guillermo Lora-Tamayo, Jaime Arrieta, Estibaliz García-Reyne, Ana Losada, Irene de Miguel, Borja Díaz-Simón, Raquel López-Medrano, Francisco Fernández-Ruiz, Mario Carretero, Octavio San Juan, Rafael Aguado, José María Lumbreras, Carlos Eur J Clin Microbiol Infect Dis Original Article The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All hospitalized adult patients with a diagnosis of SARS-CoV-2 infection by rRT-PCR performed on a nasopharingeal sample from March 1 to March 18 in our institution were included. The study population was divided according to the Ct value obtained upon admission in patients with high viral load (Ct < 25), intermediate viral load (Ct: 25–30) and low viral load (Ct > 30). Demographic, clinical and laboratory variables of the different groups were analyzed to assess the influence of viral load on the development of respiratory failure during admission. Overall, 455 sequential patients were included. The median Ct value was 28 (IQR: 24–32). One hundred and thirty patients (28.6%) had a high viral load, 175 (38.5%) an intermediate viral load and 150 (33%) a low viral load. Advanced age, male sex, presence of cardiovascular disease and laboratory markers such as lactate dehydrogenase, lymphocyte count and C-reactive protein, as well as a high viral load on admission, were predictive of respiratory failure. A Ct value < 25 was associated with a higher risk of respiratory failure during admission (OR: 2.99, 95%IC: 1.57–5.69). SARS-CoV-2 viral load, measured through the Ct value on admission, is a valuable tool to predict the development of respiratory failure in COVID-19 inpatients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04150-w. Springer Berlin Heidelberg 2021-01-07 2021 /pmc/articles/PMC7787698/ /pubmed/33409832 http://dx.doi.org/10.1007/s10096-020-04150-w Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article de la Calle, Cristina Lalueza, Antonio Mancheño-Losa, Mikel Maestro-de la Calle, Guillermo Lora-Tamayo, Jaime Arrieta, Estibaliz García-Reyne, Ana Losada, Irene de Miguel, Borja Díaz-Simón, Raquel López-Medrano, Francisco Fernández-Ruiz, Mario Carretero, Octavio San Juan, Rafael Aguado, José María Lumbreras, Carlos Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection |
title | Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection |
title_full | Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection |
title_fullStr | Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection |
title_full_unstemmed | Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection |
title_short | Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection |
title_sort | impact of viral load at admission on the development of respiratory failure in hospitalized patients with sars-cov-2 infection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787698/ https://www.ncbi.nlm.nih.gov/pubmed/33409832 http://dx.doi.org/10.1007/s10096-020-04150-w |
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