Amphiphilic Polymer-Modified Uniform CuFeSe(2) Nanoparticles for CT/MR Dual-Modal Imaging

Recently, magnetic photothermal nanomaterials have attracted much attention in the diagnosis and treatment of cancer. In this study, we developed the ultrasmall magnetic CuFeSe(2) nanoparticles for CT/MR dual-modal imaging. By controlling the reaction time and condition, CuFeSe(2) nanoparticles were...

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Detalles Bibliográficos
Autores principales: Wu, Min, Fu, Shaozhi, Shu, Jian, Yu, Kequan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787810/
https://www.ncbi.nlm.nih.gov/pubmed/33456402
http://dx.doi.org/10.1155/2020/4891325
Descripción
Sumario:Recently, magnetic photothermal nanomaterials have attracted much attention in the diagnosis and treatment of cancer. In this study, we developed the ultrasmall magnetic CuFeSe(2) nanoparticles for CT/MR dual-modal imaging. By controlling the reaction time and condition, CuFeSe(2) nanoparticles were synthesized by a simple directly aqueous method. After modification with copolymer methoxy polyethylene glycol-polycaprolactone (MPEG-PCL), the obtained MPEG-PCL@CuFeSe(2) nanoparticles showed excellent water solubility, colloidal stability, and biocompatibility. In addition, they also exhibited superparamagnetism and X-ray's characteristics. For these properties, they will become ideal nanomaterials for CT/MR dual-modal imaging.

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