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Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection

The coexistence of cystic echinococcosis (CE) and aspergilloma is rather uncommon. Aspergillus species, saprophytic fungi, can colonize pulmonary cavities that are caused by tuberculosis, sarcoidosis, and CE. Infection by Aspergillus is often occurring in immunosuppressed patients. However, coinfect...

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Autores principales: Zareshahrabadi, Zahra, Sarkari, Bahador, Shamsolvaezin, Nadereh, Ziaian, Bizhan, Tootoonchi, Alireza, Shahriarirad, Reza, Zomorodian, Kamiar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787855/
https://www.ncbi.nlm.nih.gov/pubmed/33457026
http://dx.doi.org/10.1155/2020/6650478
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author Zareshahrabadi, Zahra
Sarkari, Bahador
Shamsolvaezin, Nadereh
Ziaian, Bizhan
Tootoonchi, Alireza
Shahriarirad, Reza
Zomorodian, Kamiar
author_facet Zareshahrabadi, Zahra
Sarkari, Bahador
Shamsolvaezin, Nadereh
Ziaian, Bizhan
Tootoonchi, Alireza
Shahriarirad, Reza
Zomorodian, Kamiar
author_sort Zareshahrabadi, Zahra
collection PubMed
description The coexistence of cystic echinococcosis (CE) and aspergilloma is rather uncommon. Aspergillus species, saprophytic fungi, can colonize pulmonary cavities that are caused by tuberculosis, sarcoidosis, and CE. Infection by Aspergillus is often occurring in immunosuppressed patients. However, coinfection of aspergilloma with pulmonary hydatid cyst is very unusual, especially in an immunocompetent patient with unruptured cyst. Herein, we report a case of lung hydatid cyst coinfected with Aspergillus in a 42-year-old Iranian man from Southern Iran. Chest X-ray and computed tomography (CT) scan showed a circumscribed cystic lesion in the superior and inferior segment of the lower lobes of right and left lungs that suggests hydatid cyst. Radical surgery (lobectomy) was performed for the patient. Histopathological evaluation reconfirmed the classical laminated layer of hydatid cyst. Moreover, the ectocyst layer of the right lung showed the presence of numerous cluster septate hyphae with acute-angled branching, as seen in the morphology of Aspergillus species. DNA was extracted from the cyst, and the ITS1-5.8s-ITS2 region of the fungal agent was amplified. Sequencing and analysis of seminested PCR product revealed that the isolate has the most similarity with Aspergillus niger. Further attention is recommended to control fungal pathogens during pulmonary hydatidosis. The coexistence of aspergilloma should always be kept in mind for the better management of CE.
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spelling pubmed-77878552021-01-14 Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection Zareshahrabadi, Zahra Sarkari, Bahador Shamsolvaezin, Nadereh Ziaian, Bizhan Tootoonchi, Alireza Shahriarirad, Reza Zomorodian, Kamiar Case Rep Infect Dis Case Report The coexistence of cystic echinococcosis (CE) and aspergilloma is rather uncommon. Aspergillus species, saprophytic fungi, can colonize pulmonary cavities that are caused by tuberculosis, sarcoidosis, and CE. Infection by Aspergillus is often occurring in immunosuppressed patients. However, coinfection of aspergilloma with pulmonary hydatid cyst is very unusual, especially in an immunocompetent patient with unruptured cyst. Herein, we report a case of lung hydatid cyst coinfected with Aspergillus in a 42-year-old Iranian man from Southern Iran. Chest X-ray and computed tomography (CT) scan showed a circumscribed cystic lesion in the superior and inferior segment of the lower lobes of right and left lungs that suggests hydatid cyst. Radical surgery (lobectomy) was performed for the patient. Histopathological evaluation reconfirmed the classical laminated layer of hydatid cyst. Moreover, the ectocyst layer of the right lung showed the presence of numerous cluster septate hyphae with acute-angled branching, as seen in the morphology of Aspergillus species. DNA was extracted from the cyst, and the ITS1-5.8s-ITS2 region of the fungal agent was amplified. Sequencing and analysis of seminested PCR product revealed that the isolate has the most similarity with Aspergillus niger. Further attention is recommended to control fungal pathogens during pulmonary hydatidosis. The coexistence of aspergilloma should always be kept in mind for the better management of CE. Hindawi 2020-12-12 /pmc/articles/PMC7787855/ /pubmed/33457026 http://dx.doi.org/10.1155/2020/6650478 Text en Copyright © 2020 Zahra Zareshahrabadi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zareshahrabadi, Zahra
Sarkari, Bahador
Shamsolvaezin, Nadereh
Ziaian, Bizhan
Tootoonchi, Alireza
Shahriarirad, Reza
Zomorodian, Kamiar
Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection
title Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection
title_full Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection
title_fullStr Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection
title_full_unstemmed Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection
title_short Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection
title_sort concomitant of pulmonary hydatid cyst and aspergilloma: a rare coinfection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787855/
https://www.ncbi.nlm.nih.gov/pubmed/33457026
http://dx.doi.org/10.1155/2020/6650478
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