Antisense oligonucleotide and adjuvant exercise therapy reverse fatigue in old mice with myotonic dystrophy

Patients with myotonic dystrophy type 1 (DM1) identify chronic fatigue as the most debilitating symptom, which manifests in part as prolonged recovery after exercise. Clinical features of DM1 result from pathogenic gain-of-function activity of transcripts containing an expanded microsatellite CUG re...

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Detalles Bibliográficos
Autores principales: Hu, Ningyan, Kim, Eunjoo, Antoury, Layal, Li, Jia, González-Pérez, Paloma, Rutkove, Seward B., Wheeler, Thurman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787993/
https://www.ncbi.nlm.nih.gov/pubmed/33473325
http://dx.doi.org/10.1016/j.omtn.2020.11.014

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