Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry

There is an urgent demand to develop new technologies to characterize immunogenicity to biotherapeutics. Here, we developed an immunocapture LC-MS assay to isotype and semi-quantify monkey anti-drug antibodies (ADAs) to fully human monoclonal antibody (mAb) drugs. ADAs were isolated from serum sampl...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoxiao, Xu, Xiaobin, Partridge, Michael A., Chen, Jihua, Koehler-Stec, Ellen, Sumner, Giane, Qiu, Haibo, Torri, Albert, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788027/
https://www.ncbi.nlm.nih.gov/pubmed/33404777
http://dx.doi.org/10.1208/s12248-020-00538-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788027/
https://www.ncbi.nlm.nih.gov/pubmed/33404777
http://dx.doi.org/10.1208/s12248-020-00538-w

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