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LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common prelude to cirrhosis and hepatocellular carcinoma. The genetic rs641738 C>T variant in the lysophosphatidylinositol acyltransferase 1 (LPIAT1)/membrane bound O-acyltransferase domain-containing 7, which incorporates arachidonic acid...

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Detalles Bibliográficos
Autores principales:	Tanaka, Yuki, Shimanaka, Yuta, Caddeo, Andrea, Kubo, Takuya, Mao, Yanli, Kubota, Tetsuya, Kubota, Naoto, Yamauchi, Toshimasa, Mancina, Rosellina Margherita, Baselli, Guido, Luukkonen, Panu, Pihlajamäki, Jussi, Yki-Järvinen, Hannele, Valenti, Luca, Arai, Hiroyuki, Romeo, Stefano, Kono, Nozomu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788230/ https://www.ncbi.nlm.nih.gov/pubmed/32253259 http://dx.doi.org/10.1136/gutjnl-2020-320646

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