Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved. We demonstrate here that ATM-deficient cells are exquisitely sensitive to nutrient deprivation, which can be explained by de...

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Detalles Bibliográficos
Autores principales: Yeo, Abrey J., Chong, Kok L., Gatei, Magtouf, Zou, Dongxiu, Stewart, Romal, Withey, Sarah, Wolvetang, Ernst, Parton, Robert G., Brown, Adam D., Kastan, Michael B., Coman, David, Lavin, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788243/
https://www.ncbi.nlm.nih.gov/pubmed/33437944
http://dx.doi.org/10.1016/j.isci.2020.101972

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