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Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine

BACKGROUND & AIMS: Transient expression of Neurog3 commits intestinal secretory progenitors to become enteroendocrine-biased progenitors and hence drive enteroendocrine differentiation. Loss of Neurog3 in mouse resulted in the depletion of intestinal enteroendocrine cells (EECs) and an increase...

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Detalles Bibliográficos
Autores principales:	Li, Hui Joyce, Ray, Subir K., Kucukural, Alper, Gradwohl, Gerard, Leiter, Andrew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788244/ https://www.ncbi.nlm.nih.gov/pubmed/32822913 http://dx.doi.org/10.1016/j.jcmgh.2020.08.006

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