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Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress

Constitutively active extracellular signal–regulated kinase (ERK) 1/2 signaling promotes cancer cell proliferation and survival. We previously described a class of compounds containing a 1,1-dioxido-2,5-dihydrothiophen-3-yl 4-benzenesulfonate scaffold that targeted ERK2 substrate docking sites and s...

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Detalles Bibliográficos
Autores principales:	Martinez, Ramon, Huang, Weiliang, Samadani, Ramin, Mackowiak, Bryan, Centola, Garrick, Chen, Lijia, Conlon, Ivie L., Hom, Kellie, Kane, Maureen A., Fletcher, Steven, Shapiro, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Drug Discovery and Translational Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788356/ https://www.ncbi.nlm.nih.gov/pubmed/33109619 http://dx.doi.org/10.1124/jpet.120.000266

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