The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity

Novel functional coding sequences (altORFs) are camouflaged within annotated ones (CDS) in a different reading frame. We show here that an altORF is nested in the FUS CDS, encoding a conserved 170 amino acid protein, altFUS. AltFUS is endogenously expressed in human tissues, notably in the motor cor...

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Detalles Bibliográficos
Autores principales: Brunet, Marie A, Jacques, Jean‐Francois, Nassari, Sonya, Tyzack, Giulia E, McGoldrick, Philip, Zinman, Lorne, Jean, Steve, Robertson, Janice, Patani, Rickie, Roucou, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788448/
https://www.ncbi.nlm.nih.gov/pubmed/33226175
http://dx.doi.org/10.15252/embr.202050640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788448/
https://www.ncbi.nlm.nih.gov/pubmed/33226175
http://dx.doi.org/10.15252/embr.202050640

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