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Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews

AIMS: The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett’s oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review in the Netherlands, a web-based digital review panel has been set up, which cur...

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Autores principales: Klaver, Esther, van der Wel, Myrtle, Duits, Lucas, Pouw, Roos, Seldenrijk, Kees, Offerhaus, Johan, Visser, Mike, ten Kate, Fiebo, Biermann, Katharina, Brosens, Lodewijk, Doukas, Michael, Huysentruyt, Clément, Karrenbeld, Arend, Kats-Ugurlu, Gursah, van der Laan, Jaap, van Lijnschoten, Ineke, Moll, Freek, Ooms, Ariadne, Tijssen, Jan, Meijer, Sybren, Bergman, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788478/
https://www.ncbi.nlm.nih.gov/pubmed/32467320
http://dx.doi.org/10.1136/jclinpath-2020-206511
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author Klaver, Esther
van der Wel, Myrtle
Duits, Lucas
Pouw, Roos
Seldenrijk, Kees
Offerhaus, Johan
Visser, Mike
ten Kate, Fiebo
Biermann, Katharina
Brosens, Lodewijk
Doukas, Michael
Huysentruyt, Clément
Karrenbeld, Arend
Kats-Ugurlu, Gursah
van der Laan, Jaap
van Lijnschoten, Ineke
Moll, Freek
Ooms, Ariadne
Tijssen, Jan
Meijer, Sybren
Bergman, Jacques
author_facet Klaver, Esther
van der Wel, Myrtle
Duits, Lucas
Pouw, Roos
Seldenrijk, Kees
Offerhaus, Johan
Visser, Mike
ten Kate, Fiebo
Biermann, Katharina
Brosens, Lodewijk
Doukas, Michael
Huysentruyt, Clément
Karrenbeld, Arend
Kats-Ugurlu, Gursah
van der Laan, Jaap
van Lijnschoten, Ineke
Moll, Freek
Ooms, Ariadne
Tijssen, Jan
Meijer, Sybren
Bergman, Jacques
author_sort Klaver, Esther
collection PubMed
description AIMS: The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett’s oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review in the Netherlands, a web-based digital review panel has been set up, which currently consists of eight ‘core’ pathologists. The aim of this study was to evaluate if other pathologists from the Dutch BO expert centres qualify for the expert panel by assessing their performance in 80 consecutive LGD reviews submitted to the panel. METHODS: Pathologists independently assessed digital slides in two phases. Both phases consisted of 40 cases, with a group discussion after phase I. For all cases, a previous consensus diagnosis made by five core pathologists was available, which was used as reference. The following criteria were used: (1) percentage of ‘indefinite for dysplasia’ diagnoses, (2) percentage agreement with consensus diagnosis and (3) proportion of cases with a consensus diagnosis of dysplasia underdiagnosed as non-dysplastic. Benchmarks were based on scores of the core pathologists. RESULTS: After phase I, 1/7 pathologists met the benchmark score for all quality criteria, yet three pathologists only marginally failed the agreement with consensus diagnosis (score 68.3%, benchmark 69%). After a group discussion and phase II, 5/6 remaining aspirant panel members qualified with all scores within the benchmark range. CONCLUSIONS: The Dutch BO review panel now consists of 14 pathologists, who—after structured assessments and group discussions—can be considered homogeneous in their review of biopsies with LGD.
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spelling pubmed-77884782021-01-14 Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews Klaver, Esther van der Wel, Myrtle Duits, Lucas Pouw, Roos Seldenrijk, Kees Offerhaus, Johan Visser, Mike ten Kate, Fiebo Biermann, Katharina Brosens, Lodewijk Doukas, Michael Huysentruyt, Clément Karrenbeld, Arend Kats-Ugurlu, Gursah van der Laan, Jaap van Lijnschoten, Ineke Moll, Freek Ooms, Ariadne Tijssen, Jan Meijer, Sybren Bergman, Jacques J Clin Pathol Original Research AIMS: The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett’s oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review in the Netherlands, a web-based digital review panel has been set up, which currently consists of eight ‘core’ pathologists. The aim of this study was to evaluate if other pathologists from the Dutch BO expert centres qualify for the expert panel by assessing their performance in 80 consecutive LGD reviews submitted to the panel. METHODS: Pathologists independently assessed digital slides in two phases. Both phases consisted of 40 cases, with a group discussion after phase I. For all cases, a previous consensus diagnosis made by five core pathologists was available, which was used as reference. The following criteria were used: (1) percentage of ‘indefinite for dysplasia’ diagnoses, (2) percentage agreement with consensus diagnosis and (3) proportion of cases with a consensus diagnosis of dysplasia underdiagnosed as non-dysplastic. Benchmarks were based on scores of the core pathologists. RESULTS: After phase I, 1/7 pathologists met the benchmark score for all quality criteria, yet three pathologists only marginally failed the agreement with consensus diagnosis (score 68.3%, benchmark 69%). After a group discussion and phase II, 5/6 remaining aspirant panel members qualified with all scores within the benchmark range. CONCLUSIONS: The Dutch BO review panel now consists of 14 pathologists, who—after structured assessments and group discussions—can be considered homogeneous in their review of biopsies with LGD. BMJ Publishing Group 2021-01 2020-05-28 /pmc/articles/PMC7788478/ /pubmed/32467320 http://dx.doi.org/10.1136/jclinpath-2020-206511 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Klaver, Esther
van der Wel, Myrtle
Duits, Lucas
Pouw, Roos
Seldenrijk, Kees
Offerhaus, Johan
Visser, Mike
ten Kate, Fiebo
Biermann, Katharina
Brosens, Lodewijk
Doukas, Michael
Huysentruyt, Clément
Karrenbeld, Arend
Kats-Ugurlu, Gursah
van der Laan, Jaap
van Lijnschoten, Ineke
Moll, Freek
Ooms, Ariadne
Tijssen, Jan
Meijer, Sybren
Bergman, Jacques
Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews
title Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews
title_full Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews
title_fullStr Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews
title_full_unstemmed Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews
title_short Performance of gastrointestinal pathologists within a national digital review panel for Barrett’s oesophagus in the Netherlands: results of 80 prospective biopsy reviews
title_sort performance of gastrointestinal pathologists within a national digital review panel for barrett’s oesophagus in the netherlands: results of 80 prospective biopsy reviews
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788478/
https://www.ncbi.nlm.nih.gov/pubmed/32467320
http://dx.doi.org/10.1136/jclinpath-2020-206511
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