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MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

The MRE11-RAD50-NBS1 (MRN) complex supports the synthesis of damage-induced long non-coding RNA (dilncRNA) by RNA polymerase II (RNAPII) from DNA double-strand breaks (DSBs) by an unknown mechanism. Here, we show that recombinant human MRN and native RNAPII are sufficient to reconstitute a minimal f...

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Detalles Bibliográficos
Autores principales:	Sharma, Sheetal, Anand, Roopesh, Zhang, Xuzhu, Francia, Sofia, Michelini, Flavia, Galbiati, Alessandro, Williams, Hannah, Ronato, Daryl A., Masson, Jean-Yves, Rothenberg, Eli, Cejka, Petr, d’Adda di Fagagna, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788559/ https://www.ncbi.nlm.nih.gov/pubmed/33406426 http://dx.doi.org/10.1016/j.celrep.2020.108565

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