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Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates

[Image: see text] (R)-[(11)C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) function at the blood–brain barrier (BBB). Several studies have evaluated the pharmacokinetics of (R)-[(11)C]verapamil in rats and humans under different conditions. However, to the be...

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Detalles Bibliográficos
Autores principales:	García-Varela, Lara, García, David Vállez, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Tago, Tetsuro, Elsinga, Philip H., Tsukada, Hideo, Colabufo, Nicola A., Dierckx, Rudi A.J.O., van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788571/ https://www.ncbi.nlm.nih.gov/pubmed/33315404 http://dx.doi.org/10.1021/acs.molpharmaceut.0c01014

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