Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that most often presents with painful ulcerations of violaceous borders in lower limbs and/or trunk. PG treatment varies according to the severity of the lesion and may either respond to local therapies or require immunosuppressive agents. In th...

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Autores principales: RIERA, Julia, MUSURUANA, Jorge, COSTA, Cecilia, CAVALLASCA, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish League Against Rheumatism 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788644/
https://www.ncbi.nlm.nih.gov/pubmed/33458671
http://dx.doi.org/10.46497/ArchRheumatol.2020.7498
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author RIERA, Julia
MUSURUANA, Jorge
COSTA, Cecilia
CAVALLASCA, Javier
author_facet RIERA, Julia
MUSURUANA, Jorge
COSTA, Cecilia
CAVALLASCA, Javier
author_sort RIERA, Julia
collection PubMed
description Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that most often presents with painful ulcerations of violaceous borders in lower limbs and/or trunk. PG treatment varies according to the severity of the lesion and may either respond to local therapies or require immunosuppressive agents. In this article, we present the case of an antiphospholipid antibody-positive 59-year-old female patient diagnosed with granulomatosis with polyangiitis who developed severe PG-like skin involvement that was responsive to rituximab therapy.
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spelling pubmed-77886442021-01-14 Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies RIERA, Julia MUSURUANA, Jorge COSTA, Cecilia CAVALLASCA, Javier Arch Rheumatol Case Report Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that most often presents with painful ulcerations of violaceous borders in lower limbs and/or trunk. PG treatment varies according to the severity of the lesion and may either respond to local therapies or require immunosuppressive agents. In this article, we present the case of an antiphospholipid antibody-positive 59-year-old female patient diagnosed with granulomatosis with polyangiitis who developed severe PG-like skin involvement that was responsive to rituximab therapy. Turkish League Against Rheumatism 2020-01-08 /pmc/articles/PMC7788644/ /pubmed/33458671 http://dx.doi.org/10.46497/ArchRheumatol.2020.7498 Text en Copyright © 2020, Turkish League Against Rheumatism http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Report
RIERA, Julia
MUSURUANA, Jorge
COSTA, Cecilia
CAVALLASCA, Javier
Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies
title Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies
title_full Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies
title_fullStr Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies
title_full_unstemmed Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies
title_short Efficacy of Rituximab for Refractory Pyoderma Gangrenosum-Like Ulcers in Granulomatosis With Polyangiitis Associated to Antiphospholipid Antibodies
title_sort efficacy of rituximab for refractory pyoderma gangrenosum-like ulcers in granulomatosis with polyangiitis associated to antiphospholipid antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788644/
https://www.ncbi.nlm.nih.gov/pubmed/33458671
http://dx.doi.org/10.46497/ArchRheumatol.2020.7498
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