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Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis
BACKGROUND: It is unclear whether increased left ventricular (LV) thickness is associated with worse clinical outcomes in severe aortic stenosis (AS). The aim of this study was to determine the effect of increased LV wall thickness (LVWT) on major clinical outcomes in patients with severe AS. METHOD...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788729/ https://www.ncbi.nlm.nih.gov/pubmed/33407517 http://dx.doi.org/10.1186/s12947-020-00234-x |
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author | Park, Kyungil Park, Tae-Ho Jo, Yoon-Seong Cho, Young-Rak Park, Jong-Sung Kim, Moo-Hyun Kim, Young-Dae |
author_facet | Park, Kyungil Park, Tae-Ho Jo, Yoon-Seong Cho, Young-Rak Park, Jong-Sung Kim, Moo-Hyun Kim, Young-Dae |
author_sort | Park, Kyungil |
collection | PubMed |
description | BACKGROUND: It is unclear whether increased left ventricular (LV) thickness is associated with worse clinical outcomes in severe aortic stenosis (AS). The aim of this study was to determine the effect of increased LV wall thickness (LVWT) on major clinical outcomes in patients with severe AS. METHODS AND RESULTS: This study included 290 severe AS patients (mean age 69.4 ± 11.0 years; 136 females) between January 2008 and December 2018. For outcome assessment, the endpoint was defined as death from all causes, cardiovascular death, and the aortic valve replacement (AVR) surgery rate. During follow-up (48.7 ± 39.0 months), 157 patients had AVR, 43 patients died, and 28 patients died from cardiovascular causes. Patients with increased LVWT underwent AVR surgery much more than those without LVWT (60.0% vs. 39.0%, p < 0.001). Furthermore, in patients with increased LVWT, the all-cause and cardiovascular death rates were significantly lower in the AVR group than in the non-AVR group (8.8% vs. 27.3%, p < 0.001, 4.8%, vs. 21.0%, p < 0.001). Multivariate analysis revealed that increased LVWT, age, dyspnea, and AVR surgery were significantly correlated with cardiovascular death. CONCLUSIONS: In patients with severe AS, increased LVWT was associated with a higher AVR surgery rate and an increased rate of cardiovascular death independent of other well-known prognostic variates. Thus, these findings suggest that increased LVWT might be used as a potential prognostic factor in severe AS patients. |
format | Online Article Text |
id | pubmed-7788729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77887292021-01-07 Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis Park, Kyungil Park, Tae-Ho Jo, Yoon-Seong Cho, Young-Rak Park, Jong-Sung Kim, Moo-Hyun Kim, Young-Dae Cardiovasc Ultrasound Research BACKGROUND: It is unclear whether increased left ventricular (LV) thickness is associated with worse clinical outcomes in severe aortic stenosis (AS). The aim of this study was to determine the effect of increased LV wall thickness (LVWT) on major clinical outcomes in patients with severe AS. METHODS AND RESULTS: This study included 290 severe AS patients (mean age 69.4 ± 11.0 years; 136 females) between January 2008 and December 2018. For outcome assessment, the endpoint was defined as death from all causes, cardiovascular death, and the aortic valve replacement (AVR) surgery rate. During follow-up (48.7 ± 39.0 months), 157 patients had AVR, 43 patients died, and 28 patients died from cardiovascular causes. Patients with increased LVWT underwent AVR surgery much more than those without LVWT (60.0% vs. 39.0%, p < 0.001). Furthermore, in patients with increased LVWT, the all-cause and cardiovascular death rates were significantly lower in the AVR group than in the non-AVR group (8.8% vs. 27.3%, p < 0.001, 4.8%, vs. 21.0%, p < 0.001). Multivariate analysis revealed that increased LVWT, age, dyspnea, and AVR surgery were significantly correlated with cardiovascular death. CONCLUSIONS: In patients with severe AS, increased LVWT was associated with a higher AVR surgery rate and an increased rate of cardiovascular death independent of other well-known prognostic variates. Thus, these findings suggest that increased LVWT might be used as a potential prognostic factor in severe AS patients. BioMed Central 2021-01-06 /pmc/articles/PMC7788729/ /pubmed/33407517 http://dx.doi.org/10.1186/s12947-020-00234-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Park, Kyungil Park, Tae-Ho Jo, Yoon-Seong Cho, Young-Rak Park, Jong-Sung Kim, Moo-Hyun Kim, Young-Dae Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
title | Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
title_full | Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
title_fullStr | Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
title_full_unstemmed | Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
title_short | Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
title_sort | prognostic effect of increased left ventricular wall thickness in severe aortic stenosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788729/ https://www.ncbi.nlm.nih.gov/pubmed/33407517 http://dx.doi.org/10.1186/s12947-020-00234-x |
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