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Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort
OBJECTIVE: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. METHODS: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current st...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788797/ https://www.ncbi.nlm.nih.gov/pubmed/33407712 http://dx.doi.org/10.1186/s13041-020-00718-x |
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author | Liang, Xiao Cheng, ShiQiang Ye, Jing Chu, XiaoMeng Wen, Yan Liu, Li Qi, Xin Jia, YuMeng Zhang, Feng |
author_facet | Liang, Xiao Cheng, ShiQiang Ye, Jing Chu, XiaoMeng Wen, Yan Liu, Li Qi, Xin Jia, YuMeng Zhang, Feng |
author_sort | Liang, Xiao |
collection | PubMed |
description | OBJECTIVE: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. METHODS: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, gene-environment-wide interaction study (GEWIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0. RESULTS: We observed positive association between SHBG and the frequency of alcohol consumption (b = 0.0101, p = 3.84 × 10(–11)) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b = 0.0128, p = 1.96 × 10(–8)) in middle-aged males. Moreover, bioavailable testosterone was associated with the fluid intelligence (b = − 0.0136, p = 5.74 × 10(–5)) in middle-aged females. Finally, GEWIS identified one significant loci, Tenascin R (TNR) (rs34633780, p = 3.45 × 10(–8)) interacting with total testosterone for fluid intelligence. CONCLUSION: Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK. |
format | Online Article Text |
id | pubmed-7788797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77887972021-01-07 Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort Liang, Xiao Cheng, ShiQiang Ye, Jing Chu, XiaoMeng Wen, Yan Liu, Li Qi, Xin Jia, YuMeng Zhang, Feng Mol Brain Research OBJECTIVE: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. METHODS: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, gene-environment-wide interaction study (GEWIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0. RESULTS: We observed positive association between SHBG and the frequency of alcohol consumption (b = 0.0101, p = 3.84 × 10(–11)) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b = 0.0128, p = 1.96 × 10(–8)) in middle-aged males. Moreover, bioavailable testosterone was associated with the fluid intelligence (b = − 0.0136, p = 5.74 × 10(–5)) in middle-aged females. Finally, GEWIS identified one significant loci, Tenascin R (TNR) (rs34633780, p = 3.45 × 10(–8)) interacting with total testosterone for fluid intelligence. CONCLUSION: Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK. BioMed Central 2021-01-06 /pmc/articles/PMC7788797/ /pubmed/33407712 http://dx.doi.org/10.1186/s13041-020-00718-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Liang, Xiao Cheng, ShiQiang Ye, Jing Chu, XiaoMeng Wen, Yan Liu, Li Qi, Xin Jia, YuMeng Zhang, Feng Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort |
title | Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort |
title_full | Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort |
title_fullStr | Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort |
title_full_unstemmed | Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort |
title_short | Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort |
title_sort | evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in uk biobank cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788797/ https://www.ncbi.nlm.nih.gov/pubmed/33407712 http://dx.doi.org/10.1186/s13041-020-00718-x |
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