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Suppression of TCAB1 expression induced cellular senescence by lessening proteasomal degradation of p21 in cancer cells

BACKGROUND: TCAB1, a.k.a. WRAP53β or WDR79, is an important molecule for the maintenance of Cajal bodies and critically involved in telomere elongation and DNA repair. Upregulation of TCAB1 were discovered in a variety types of cancers. However, the function of TCAB1 in tumor cell senescence remains...

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Detalles Bibliográficos
Autores principales:	Niu, Jing, Gao, Rui-Qi, Cui, Meng-Tian, Zhang, Chen-Guang, Li, Shen-Tao, Cheng, Shan, Ding, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788802/ https://www.ncbi.nlm.nih.gov/pubmed/33413389 http://dx.doi.org/10.1186/s12935-020-01745-3

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