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NRG1 fusions in breast cancer

BACKGROUND: NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The NRG1 gene encodes ligands for the HER2(ERBB2)-ERBB3 heterodimeric receptor tyrosine kinase, and the gene fusions are thought to lead to autocr...

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Detalles Bibliográficos
Autores principales:	Howarth, Karen D., Mirza, Tashfina, Cooke, Susanna L., Chin, Suet-Feung, Pole, Jessica C., Turro, Ernest, Eldridge, Matthew D., Garcia, Raquel Manzano, Rueda, Oscar M., Boursnell, Chris, Abraham, Jean E., Caldas, Carlos, Edwards, Paul A. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788813/ https://www.ncbi.nlm.nih.gov/pubmed/33413557 http://dx.doi.org/10.1186/s13058-020-01377-5

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