Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes i...

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Detalles Bibliográficos
Autores principales: Bury, Joanna J., Chambers, Annabelle, Heath, Paul R., Ince, Paul G., Shaw, Pamela J., Matthews, Fiona E., Brayne, Carol, Simpson, Julie E., Wharton, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788898/
https://www.ncbi.nlm.nih.gov/pubmed/33407907
http://dx.doi.org/10.1186/s40478-020-01109-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788898/
https://www.ncbi.nlm.nih.gov/pubmed/33407907
http://dx.doi.org/10.1186/s40478-020-01109-y

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