Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy

Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling...

Descripción completa

Detalles Bibliográficos
Autores principales: Xuan, Xiuyun, Zhang, Lin, Tian, Chunxia, Wu, Ting, Ye, Haihua, Cao, Juanmei, Chen, Fangqi, Liang, Yan, Yang, Huilan, Huang, Changzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788945/
https://www.ncbi.nlm.nih.gov/pubmed/33407883
http://dx.doi.org/10.1186/s13578-020-00504-1
_version_ 1783633134287323136
author Xuan, Xiuyun
Zhang, Lin
Tian, Chunxia
Wu, Ting
Ye, Haihua
Cao, Juanmei
Chen, Fangqi
Liang, Yan
Yang, Huilan
Huang, Changzheng
author_facet Xuan, Xiuyun
Zhang, Lin
Tian, Chunxia
Wu, Ting
Ye, Haihua
Cao, Juanmei
Chen, Fangqi
Liang, Yan
Yang, Huilan
Huang, Changzheng
author_sort Xuan, Xiuyun
collection PubMed
description Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling pathway. It has recently been reported that IL-22 also contributes to the pathogenesis of many connective tissue diseases (CTDs). In this review, we will discuss the role of IL-22 in several CTDs, such as system lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, systemic sclerosis and dermatomyositis, suggesting that IL-22 may be a potential therapeutic target in CTDs.
format Online
Article
Text
id pubmed-7788945
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-77889452021-01-07 Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy Xuan, Xiuyun Zhang, Lin Tian, Chunxia Wu, Ting Ye, Haihua Cao, Juanmei Chen, Fangqi Liang, Yan Yang, Huilan Huang, Changzheng Cell Biosci Review Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling pathway. It has recently been reported that IL-22 also contributes to the pathogenesis of many connective tissue diseases (CTDs). In this review, we will discuss the role of IL-22 in several CTDs, such as system lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, systemic sclerosis and dermatomyositis, suggesting that IL-22 may be a potential therapeutic target in CTDs. BioMed Central 2021-01-06 /pmc/articles/PMC7788945/ /pubmed/33407883 http://dx.doi.org/10.1186/s13578-020-00504-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xuan, Xiuyun
Zhang, Lin
Tian, Chunxia
Wu, Ting
Ye, Haihua
Cao, Juanmei
Chen, Fangqi
Liang, Yan
Yang, Huilan
Huang, Changzheng
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
title Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
title_full Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
title_fullStr Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
title_full_unstemmed Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
title_short Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
title_sort interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788945/
https://www.ncbi.nlm.nih.gov/pubmed/33407883
http://dx.doi.org/10.1186/s13578-020-00504-1
work_keys_str_mv AT xuanxiuyun interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT zhanglin interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT tianchunxia interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT wuting interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT yehaihua interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT caojuanmei interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT chenfangqi interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT liangyan interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT yanghuilan interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy
AT huangchangzheng interleukin22andconnectivetissuediseasesemergingroleinpathogenesisandtherapy

Ejemplares similares