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Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility
BACKGROUND: This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility. METHODS: We retrospectively analyzed the clinical data of 854 cycl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788974/ https://www.ncbi.nlm.nih.gov/pubmed/33407250 http://dx.doi.org/10.1186/s12884-020-03495-6 |
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author | Bo, Wenjia Zhang, Ning Wang, Ling Guo, Ying Wu, Haicui |
author_facet | Bo, Wenjia Zhang, Ning Wang, Ling Guo, Ying Wu, Haicui |
author_sort | Bo, Wenjia |
collection | PubMed |
description | BACKGROUND: This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility. METHODS: We retrospectively analyzed the clinical data of 854 cycles due to fallopian tube associated infertility in vitro fertilization fresh embryo transfer. The clinical data had been collected from January 2010 to December 2018 and was divided into 7 groups depending on the progesterone level on human chorionic gonadotropin administration day. Live birth rates and observation trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups; Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone ≥ 1.25 ng/ml). We then compared the ovulation results and clinical outcomes among the 3 groups. RESULTS: There were no significant differences in age, infertility years, gonadotropin dosage, gonadotropin days, Luteinizing hormone level on human chorionic gonadotropin day, 2 pronuclear fertilization rates, clinical pregnancy rates, live birth rates, full-term birth rate, and preterm birth rates among the three groups. However body mass index (p = 0.001), basal luteinizing hormone (p = 0.034), estrogen peak (p < 0.001), number of oocytes obtained (P < 0.001) were significantly different. CONCLUSIONS: Progesterone level on human chorionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0 and 1.25 ng/ml may lead to good clinical pregnancy outcomes. |
format | Online Article Text |
id | pubmed-7788974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77889742021-01-07 Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility Bo, Wenjia Zhang, Ning Wang, Ling Guo, Ying Wu, Haicui BMC Pregnancy Childbirth Research Article BACKGROUND: This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility. METHODS: We retrospectively analyzed the clinical data of 854 cycles due to fallopian tube associated infertility in vitro fertilization fresh embryo transfer. The clinical data had been collected from January 2010 to December 2018 and was divided into 7 groups depending on the progesterone level on human chorionic gonadotropin administration day. Live birth rates and observation trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups; Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone ≥ 1.25 ng/ml). We then compared the ovulation results and clinical outcomes among the 3 groups. RESULTS: There were no significant differences in age, infertility years, gonadotropin dosage, gonadotropin days, Luteinizing hormone level on human chorionic gonadotropin day, 2 pronuclear fertilization rates, clinical pregnancy rates, live birth rates, full-term birth rate, and preterm birth rates among the three groups. However body mass index (p = 0.001), basal luteinizing hormone (p = 0.034), estrogen peak (p < 0.001), number of oocytes obtained (P < 0.001) were significantly different. CONCLUSIONS: Progesterone level on human chorionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0 and 1.25 ng/ml may lead to good clinical pregnancy outcomes. BioMed Central 2021-01-06 /pmc/articles/PMC7788974/ /pubmed/33407250 http://dx.doi.org/10.1186/s12884-020-03495-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Bo, Wenjia Zhang, Ning Wang, Ling Guo, Ying Wu, Haicui Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
title | Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
title_full | Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
title_fullStr | Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
title_full_unstemmed | Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
title_short | Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
title_sort | progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788974/ https://www.ncbi.nlm.nih.gov/pubmed/33407250 http://dx.doi.org/10.1186/s12884-020-03495-6 |
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