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Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review
The term lipidome is mentioned to the total amount of the lipids inside the biological cells. The lipid enters the human gastrointestinal tract through external source and internal source. The absorption pathway of lipids in the gastrointestinal tract has many ways; the 1(st) way, the lipid molecule...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789067/ https://www.ncbi.nlm.nih.gov/pubmed/33505149 http://dx.doi.org/10.3748/wjg.v27.i1.37 |
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author | Koriem, Khaled Mohamed Mohamed |
author_facet | Koriem, Khaled Mohamed Mohamed |
author_sort | Koriem, Khaled Mohamed Mohamed |
collection | PubMed |
description | The term lipidome is mentioned to the total amount of the lipids inside the biological cells. The lipid enters the human gastrointestinal tract through external source and internal source. The absorption pathway of lipids in the gastrointestinal tract has many ways; the 1(st) way, the lipid molecules are digested in the lumen before go through the enterocytes, digested products are re-esterified into complex lipid molecules. The 2(nd) way, the intracellular lipids are accumulated into lipoproteins (chylomicrons) which transport lipids throughout the whole body. The lipids are re-synthesis again inside the human body where the gastrointestinal lipids are: (1) Transferred into the endoplasmic reticulum; (2) Collected as lipoproteins such as chylomicrons; or (3) Stored as lipid droplets in the cytosol. The lipids play an important role in many stages of the viral replication cycle. The specific lipid change occurs during viral infection in advanced viral replication cycle. There are 47 lipids within 11 lipid classes were significantly disturbed after viral infection. The virus connects with blood-borne lipoproteins and apolipoprotein E to change viral infectivity. The viral interest is cholesterol- and lipid raft-dependent molecules. In conclusion, lipidome is important in gastrointestinal fat absorption and coronavirus disease 2019 (COVID-19) infection so lipidome is basic in gut metabolism and in COVID-19 infection success. |
format | Online Article Text |
id | pubmed-7789067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-77890672021-01-26 Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review Koriem, Khaled Mohamed Mohamed World J Gastroenterol Minireviews The term lipidome is mentioned to the total amount of the lipids inside the biological cells. The lipid enters the human gastrointestinal tract through external source and internal source. The absorption pathway of lipids in the gastrointestinal tract has many ways; the 1(st) way, the lipid molecules are digested in the lumen before go through the enterocytes, digested products are re-esterified into complex lipid molecules. The 2(nd) way, the intracellular lipids are accumulated into lipoproteins (chylomicrons) which transport lipids throughout the whole body. The lipids are re-synthesis again inside the human body where the gastrointestinal lipids are: (1) Transferred into the endoplasmic reticulum; (2) Collected as lipoproteins such as chylomicrons; or (3) Stored as lipid droplets in the cytosol. The lipids play an important role in many stages of the viral replication cycle. The specific lipid change occurs during viral infection in advanced viral replication cycle. There are 47 lipids within 11 lipid classes were significantly disturbed after viral infection. The virus connects with blood-borne lipoproteins and apolipoprotein E to change viral infectivity. The viral interest is cholesterol- and lipid raft-dependent molecules. In conclusion, lipidome is important in gastrointestinal fat absorption and coronavirus disease 2019 (COVID-19) infection so lipidome is basic in gut metabolism and in COVID-19 infection success. Baishideng Publishing Group Inc 2021-01-07 2021-01-07 /pmc/articles/PMC7789067/ /pubmed/33505149 http://dx.doi.org/10.3748/wjg.v27.i1.37 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Koriem, Khaled Mohamed Mohamed Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review |
title | Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review |
title_full | Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review |
title_fullStr | Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review |
title_full_unstemmed | Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review |
title_short | Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review |
title_sort | lipidome is lipids regulator in gastrointestinal tract and it is a life collar in covid-19: a review |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789067/ https://www.ncbi.nlm.nih.gov/pubmed/33505149 http://dx.doi.org/10.3748/wjg.v27.i1.37 |
work_keys_str_mv | AT koriemkhaledmohamedmohamed lipidomeislipidsregulatoringastrointestinaltractanditisalifecollarincovid19areview |